Circulating microRNAs and vascular calcification in hemodialysis patients

Chien Te Lee*, Yueh Ting Lee, You Lin Tain, Hwee Yeong Ng, Wei Hung Kuo

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

11 Scopus citations

Abstract

Objective: Vascular calcification is common in chronic dialysis patients and is associated with increased morbidity and mortality. However, the role of circulating microRNAs (miRs) in vascular calcification has rarely been investigated. We aimed to determine circulating levels of miRs in hemodialysis patients, and analyzed their relationship with vascular calcification. Methods: Sixty-one stable hemodialysis patients were enrolled, including 31 with vascular calcification and 30 without. Demographic and biochemical data were collected and reviewed. The presence and severity of vascular calcification were determined by lumber spine X-ray. Blood levels of miR29a/b, miR223, miR9, and miR21 were determined. Results: Patients with vascular calcification were older (65.6 ± 9.0 vs. 59.1 ± 7.1 years) with a higher proportion of vascular disease (55% vs. 23%) than those without vascular calcification. Additionally, high-sensitivity C-reactive protein (3.90 vs 2.09 mg/dL) and fibroblast growth factor 23 (17311 vs. 6306 pg/mL) were significantly higher. Patients with vascular calcification also had higher levels of miR29a/b and miR223. Regression analysis indicated that age and miR29a were significant associates of the calcification score. Conclusions: Hemodialysis patients with vascular calcification had higher levels of miR 29a/b and miR223 than those without vascular calcification, and circulating miR29a was associated with calcification severity.

Original languageEnglish
Pages (from-to)2929-2939
Number of pages11
JournalJournal of International Medical Research
Volume47
Issue number7
DOIs
StatePublished - 01 07 2019

Bibliographical note

Publisher Copyright:
© The Author(s) 2019.

Keywords

  • C-reactive protein
  • chronic kidney disease
  • chronic kidney disease
  • fibroblast growth factor
  • hemodialysis
  • microRNA
  • osteocalcin
  • parathyroid hormone
  • vascular calcification

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