Cladieunicellins A-E, new eunicellins from an Indonesian soft coral Cladiella sp.

Yung Husan Chen; Chia Ying Tai; Yueh Hsiung Kuo; Chia Ying Kao; Jan Jung Li; Tsong Long Hwang; Lee Shing Fang; Wei Hsien Wang; Jyh Horng Sheu; Ping Jyun Sung

doi:10.1248/cpb.59.353

Cladieunicellins A-E, new eunicellins from an Indonesian soft coral Cladiella sp.

Yung Husan Chen
, Chia Ying Tai
, Yueh Hsiung Kuo
, Chia Ying Kao
, Jan Jung Li
, Tsong Long Hwang
, Lee Shing Fang
, Wei Hsien Wang
, Jyh Horng Sheu^*
, Ping Jyun Sung

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

30 Scopus citations

Abstract

Five new eunicellin-type diterpenoids, cladieunicellins A-E (1-5), were isolated from an Indonesian soft coral identified as Cladiella sp. The structures of diterpenoids 1-5 were established using spectroscopic methods. Eunicellins 2 and 5 were found to be cytotoxic against DLD-1 and HL-60 tumor cells, respectively, and 3 displayed inhibitory effects against superoxide anion generation by human neutrophils.

Original language	English
Pages (from-to)	353-358
Number of pages	6
Journal	Chemical and Pharmaceutical Bulletin
Volume	59
Issue number	3
DOIs	https://doi.org/10.1248/cpb.59.353
State	Published - 03 2011

Keywords

Cladiella
Cladieunicellin
Cytotoxicity
Eunicellin
Soft coral
Superoxide anion

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1248/cpb.59.353

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title = "Cladieunicellins A-E, new eunicellins from an Indonesian soft coral Cladiella sp.",

abstract = "Five new eunicellin-type diterpenoids, cladieunicellins A-E (1-5), were isolated from an Indonesian soft coral identified as Cladiella sp. The structures of diterpenoids 1-5 were established using spectroscopic methods. Eunicellins 2 and 5 were found to be cytotoxic against DLD-1 and HL-60 tumor cells, respectively, and 3 displayed inhibitory effects against superoxide anion generation by human neutrophils.",

keywords = "Cladiella, Cladieunicellin, Cytotoxicity, Eunicellin, Soft coral, Superoxide anion",

author = "Chen, \{Yung Husan\} and Tai, \{Chia Ying\} and Kuo, \{Yueh Hsiung\} and Kao, \{Chia Ying\} and Li, \{Jan Jung\} and Hwang, \{Tsong Long\} and Fang, \{Lee Shing\} and Wang, \{Wei Hsien\} and Sheu, \{Jyh Horng\} and Sung, \{Ping Jyun\}",

year = "2011",

month = mar,

doi = "10.1248/cpb.59.353",

language = "英语",

volume = "59",

pages = "353--358",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

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TY - JOUR

T1 - Cladieunicellins A-E, new eunicellins from an Indonesian soft coral Cladiella sp.

AU - Chen, Yung Husan

AU - Tai, Chia Ying

AU - Kuo, Yueh Hsiung

AU - Kao, Chia Ying

AU - Li, Jan Jung

AU - Hwang, Tsong Long

AU - Fang, Lee Shing

AU - Wang, Wei Hsien

AU - Sheu, Jyh Horng

AU - Sung, Ping Jyun

PY - 2011/3

Y1 - 2011/3

N2 - Five new eunicellin-type diterpenoids, cladieunicellins A-E (1-5), were isolated from an Indonesian soft coral identified as Cladiella sp. The structures of diterpenoids 1-5 were established using spectroscopic methods. Eunicellins 2 and 5 were found to be cytotoxic against DLD-1 and HL-60 tumor cells, respectively, and 3 displayed inhibitory effects against superoxide anion generation by human neutrophils.

AB - Five new eunicellin-type diterpenoids, cladieunicellins A-E (1-5), were isolated from an Indonesian soft coral identified as Cladiella sp. The structures of diterpenoids 1-5 were established using spectroscopic methods. Eunicellins 2 and 5 were found to be cytotoxic against DLD-1 and HL-60 tumor cells, respectively, and 3 displayed inhibitory effects against superoxide anion generation by human neutrophils.

KW - Cladiella

KW - Cladieunicellin

KW - Cytotoxicity

KW - Eunicellin

KW - Soft coral

KW - Superoxide anion

UR - https://www.scopus.com/pages/publications/79952394546

U2 - 10.1248/cpb.59.353

DO - 10.1248/cpb.59.353

M3 - 文章

C2 - 21372417

AN - SCOPUS:79952394546

SN - 0009-2363

VL - 59

SP - 353

EP - 358

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 3

ER -

Cladieunicellins A-E, new eunicellins from an Indonesian soft coral Cladiella sp.

Abstract

Keywords

UN SDGs

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