Class A scavenger receptors and the phagocytosis of apoptotic cells

N. Platt*, R. P. Da Silva, S. Gordon

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

39 Scopus citations

Abstract

Apoptotic cells are rarely seen in situ because of rapid clearance by phagocytes. A number of receptors have been implicated in the recognition and ingestion of dying cells. Class A scavenger receptors (SRs) are multi- domained membrane glycoproteins that can endocytose modified lipoproteins and bind a wide range of ligands. There is growing evidence that they contribute to several biological processes. We present data that suggest class A SRs are involved in the phagocytosis of apoptotic cells.

Original languageEnglish
Pages (from-to)15-19
Number of pages5
JournalImmunology Letters
Volume65
Issue number1-2
DOIs
StatePublished - 01 01 1999
Externally publishedYes

Keywords

  • Apoptosis
  • Macrophage
  • Phagocytosis
  • Scavenger receptor

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