Class A scavenger receptors and the phagocytosis of apoptotic cells

N. Platt; R. P. Da Silva; S. Gordon

doi:10.1016/S0165-2478(98)00118-7

Class A scavenger receptors and the phagocytosis of apoptotic cells

N. Platt^*
, R. P. Da Silva
, S. Gordon

^*Corresponding author for this work

University of Oxford

Research output: Contribution to journal › Journal Article › peer-review

42 Scopus citations

Abstract

Apoptotic cells are rarely seen in situ because of rapid clearance by phagocytes. A number of receptors have been implicated in the recognition and ingestion of dying cells. Class A scavenger receptors (SRs) are multi- domained membrane glycoproteins that can endocytose modified lipoproteins and bind a wide range of ligands. There is growing evidence that they contribute to several biological processes. We present data that suggest class A SRs are involved in the phagocytosis of apoptotic cells.

Original language	English
Pages (from-to)	15-19
Number of pages	5
Journal	Immunology Letters
Volume	65
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-2478(98)00118-7
State	Published - 01 01 1999
Externally published	Yes

Keywords

Apoptosis
Macrophage
Phagocytosis
Scavenger receptor

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10.1016/S0165-2478(98)00118-7

Cite this

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abstract = "Apoptotic cells are rarely seen in situ because of rapid clearance by phagocytes. A number of receptors have been implicated in the recognition and ingestion of dying cells. Class A scavenger receptors (SRs) are multi- domained membrane glycoproteins that can endocytose modified lipoproteins and bind a wide range of ligands. There is growing evidence that they contribute to several biological processes. We present data that suggest class A SRs are involved in the phagocytosis of apoptotic cells.",

keywords = "Apoptosis, Macrophage, Phagocytosis, Scavenger receptor",

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AU - Da Silva, R. P.

AU - Gordon, S.

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N2 - Apoptotic cells are rarely seen in situ because of rapid clearance by phagocytes. A number of receptors have been implicated in the recognition and ingestion of dying cells. Class A scavenger receptors (SRs) are multi- domained membrane glycoproteins that can endocytose modified lipoproteins and bind a wide range of ligands. There is growing evidence that they contribute to several biological processes. We present data that suggest class A SRs are involved in the phagocytosis of apoptotic cells.

AB - Apoptotic cells are rarely seen in situ because of rapid clearance by phagocytes. A number of receptors have been implicated in the recognition and ingestion of dying cells. Class A scavenger receptors (SRs) are multi- domained membrane glycoproteins that can endocytose modified lipoproteins and bind a wide range of ligands. There is growing evidence that they contribute to several biological processes. We present data that suggest class A SRs are involved in the phagocytosis of apoptotic cells.

KW - Apoptosis

KW - Macrophage

KW - Phagocytosis

KW - Scavenger receptor

UR - https://www.scopus.com/pages/publications/0033018443

U2 - 10.1016/S0165-2478(98)00118-7

DO - 10.1016/S0165-2478(98)00118-7

M3 - 文章

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JO - Immunology Letters

JF - Immunology Letters

IS - 1-2

ER -

Class A scavenger receptors and the phagocytosis of apoptotic cells

Abstract

Keywords

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