Classification of White Blood Cells Based on Cell Diameter, Specific Membrane Capacitance and Cytoplasmic Conductivity Leveraging Microfluidic Constriction Channel

Huiwen Tan; Minruihong Wang; Yi Zhang; Xukun Huang; Deyong Chen; Min Hsien Wu; Junbo Wang; Jian Chen

doi:10.1109/Transducers50396.2021.9495490

Classification of White Blood Cells Based on Cell Diameter, Specific Membrane Capacitance and Cytoplasmic Conductivity Leveraging Microfluidic Constriction Channel

Huiwen Tan, Minruihong Wang, Yi Zhang, Xukun Huang, Deyong Chen, Min Hsien Wu, Junbo Wang, Jian Chen

Department of Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

This paper reports the classification of white blood cells based on cell diameter Dc, specific membrane capacitance Csm and cytoplasmic conductivity \sigmacy leveraging a double T-type constriction channel based microfluidic platform. As a demonstration, Dc, Csm and \sigmacy of granulocytes (ncell=683), monocytes (ncell=203) and lymphocytes (ncell=856) were quantified as 9.23\pm 0.60 vs. 9.40\pm 0.54 vs. 6.64\pm 0.41, \ 1.22\pm 0.20 vs. 1.55\pm 0.40 vs. 1.54\pm 0.27\ Fcm2, \ 0.35\pm 0.06 vs. 0.53\pm 0.06 vs. 0.46 \pm 0.06\ Sm. Successful classification rates of white blood cells were quantified as 71.6% (Dc), 60.4% (Csm), 73.6% (\sigmacy) and 95.2% (Dc Csm \sigmacy).

Original language	English
Title of host publication	21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1028-1031
Number of pages	4
ISBN (Electronic)	9781665412674
DOIs	https://doi.org/10.1109/Transducers50396.2021.9495490
State	Published - 20 06 2021
Event	21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021 - Virtual, Online, United States Duration: 20 06 2021 → 25 06 2021

Publication series

Name	21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021

Conference

Conference	21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
Country/Territory	United States
City	Virtual, Online
Period	20/06/21 → 25/06/21

Bibliographical note

Publisher Copyright:
© 2021 IEEE.

Keywords

Cell Diameter
Classification of White Blood Cells
Cytoplasmic Conductivity
Intrinsic Bioelectrical Parameters
Microfluidic Constriction Channel
Specific Membrane Capacitance

Access to Document

10.1109/Transducers50396.2021.9495490

Cite this

Tan, H., Wang, M., Zhang, Y., Huang, X., Chen, D., Wu, M. H., Wang, J., & Chen, J. (2021). Classification of White Blood Cells Based on Cell Diameter, Specific Membrane Capacitance and Cytoplasmic Conductivity Leveraging Microfluidic Constriction Channel. In 21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021 (pp. 1028-1031). (21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/Transducers50396.2021.9495490

Tan, Huiwen ; Wang, Minruihong ; Zhang, Yi et al. / Classification of White Blood Cells Based on Cell Diameter, Specific Membrane Capacitance and Cytoplasmic Conductivity Leveraging Microfluidic Constriction Channel. 21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021. Institute of Electrical and Electronics Engineers Inc., 2021. pp. 1028-1031 (21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021).

@inproceedings{8ef78a371fd84f9c9a7a26bc9950d117,

title = "Classification of White Blood Cells Based on Cell Diameter, Specific Membrane Capacitance and Cytoplasmic Conductivity Leveraging Microfluidic Constriction Channel",

abstract = "This paper reports the classification of white blood cells based on cell diameter Dc, specific membrane capacitance Csm and cytoplasmic conductivity \sigmacy leveraging a double T-type constriction channel based microfluidic platform. As a demonstration, Dc, Csm and \sigmacy of granulocytes (ncell=683), monocytes (ncell=203) and lymphocytes (ncell=856) were quantified as 9.23\pm 0.60 vs. 9.40\pm 0.54 vs. 6.64\pm 0.41, \ 1.22\pm 0.20 vs. 1.55\pm 0.40 vs. 1.54\pm 0.27\ Fcm2, \ 0.35\pm 0.06 vs. 0.53\pm 0.06 vs. 0.46 \pm 0.06\ Sm. Successful classification rates of white blood cells were quantified as 71.6% (Dc), 60.4% (Csm), 73.6% (\sigmacy) and 95.2% (Dc Csm \sigmacy).",

keywords = "Cell Diameter, Classification of White Blood Cells, Cytoplasmic Conductivity, Intrinsic Bioelectrical Parameters, Microfluidic Constriction Channel, Specific Membrane Capacitance",

author = "Huiwen Tan and Minruihong Wang and Yi Zhang and Xukun Huang and Deyong Chen and Wu, {Min Hsien} and Junbo Wang and Jian Chen",

note = "Publisher Copyright: {\textcopyright} 2021 IEEE.; 21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021 ; Conference date: 20-06-2021 Through 25-06-2021",

year = "2021",

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doi = "10.1109/Transducers50396.2021.9495490",

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series = "21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021",

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Tan, H, Wang, M, Zhang, Y, Huang, X, Chen, D, Wu, MH, Wang, J & Chen, J 2021, Classification of White Blood Cells Based on Cell Diameter, Specific Membrane Capacitance and Cytoplasmic Conductivity Leveraging Microfluidic Constriction Channel. in 21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021. 21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021, Institute of Electrical and Electronics Engineers Inc., pp. 1028-1031, 21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021, Virtual, Online, United States, 20/06/21. https://doi.org/10.1109/Transducers50396.2021.9495490

Classification of White Blood Cells Based on Cell Diameter, Specific Membrane Capacitance and Cytoplasmic Conductivity Leveraging Microfluidic Constriction Channel. / Tan, Huiwen; Wang, Minruihong; Zhang, Yi et al.
21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021. Institute of Electrical and Electronics Engineers Inc., 2021. p. 1028-1031 (21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Classification of White Blood Cells Based on Cell Diameter, Specific Membrane Capacitance and Cytoplasmic Conductivity Leveraging Microfluidic Constriction Channel

AU - Tan, Huiwen

AU - Wang, Minruihong

AU - Zhang, Yi

AU - Huang, Xukun

AU - Chen, Deyong

AU - Wu, Min Hsien

AU - Wang, Junbo

AU - Chen, Jian

PY - 2021/6/20

Y1 - 2021/6/20

N2 - This paper reports the classification of white blood cells based on cell diameter Dc, specific membrane capacitance Csm and cytoplasmic conductivity \sigmacy leveraging a double T-type constriction channel based microfluidic platform. As a demonstration, Dc, Csm and \sigmacy of granulocytes (ncell=683), monocytes (ncell=203) and lymphocytes (ncell=856) were quantified as 9.23\pm 0.60 vs. 9.40\pm 0.54 vs. 6.64\pm 0.41, \ 1.22\pm 0.20 vs. 1.55\pm 0.40 vs. 1.54\pm 0.27\ Fcm2, \ 0.35\pm 0.06 vs. 0.53\pm 0.06 vs. 0.46 \pm 0.06\ Sm. Successful classification rates of white blood cells were quantified as 71.6% (Dc), 60.4% (Csm), 73.6% (\sigmacy) and 95.2% (Dc Csm \sigmacy).

AB - This paper reports the classification of white blood cells based on cell diameter Dc, specific membrane capacitance Csm and cytoplasmic conductivity \sigmacy leveraging a double T-type constriction channel based microfluidic platform. As a demonstration, Dc, Csm and \sigmacy of granulocytes (ncell=683), monocytes (ncell=203) and lymphocytes (ncell=856) were quantified as 9.23\pm 0.60 vs. 9.40\pm 0.54 vs. 6.64\pm 0.41, \ 1.22\pm 0.20 vs. 1.55\pm 0.40 vs. 1.54\pm 0.27\ Fcm2, \ 0.35\pm 0.06 vs. 0.53\pm 0.06 vs. 0.46 \pm 0.06\ Sm. Successful classification rates of white blood cells were quantified as 71.6% (Dc), 60.4% (Csm), 73.6% (\sigmacy) and 95.2% (Dc Csm \sigmacy).

KW - Cell Diameter

KW - Classification of White Blood Cells

KW - Cytoplasmic Conductivity

KW - Intrinsic Bioelectrical Parameters

KW - Microfluidic Constriction Channel

KW - Specific Membrane Capacitance

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DO - 10.1109/Transducers50396.2021.9495490

M3 - 会议稿件

AN - SCOPUS:85114964674

T3 - 21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021

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BT - 21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021

PB - Institute of Electrical and Electronics Engineers Inc.

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Y2 - 20 June 2021 through 25 June 2021

ER -

Tan H, Wang M, Zhang Y, Huang X, Chen D, Wu MH et al. Classification of White Blood Cells Based on Cell Diameter, Specific Membrane Capacitance and Cytoplasmic Conductivity Leveraging Microfluidic Constriction Channel. In 21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021. Institute of Electrical and Electronics Engineers Inc. 2021. p. 1028-1031. (21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021). doi: 10.1109/Transducers50396.2021.9495490

Classification of White Blood Cells Based on Cell Diameter, Specific Membrane Capacitance and Cytoplasmic Conductivity Leveraging Microfluidic Constriction Channel

Abstract

Publication series

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Bibliographical note

Keywords

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