Clerodane diterpenoids from callicarpa hypoleucophylla and their anti-inflammatory activity

Yu Chi Lin, Jue Jun Lin, Shu Rong Chen, Tsong Long Hwang, Shu Yen Fang, Michal Korinek, Ching Yeu Chen, Yun Sheng Lin, Tung Ying Wu, Ming Hong Yen, Chih Hsin Wang*, Yuan Bin Cheng

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

10 Scopus citations

Abstract

Plants of the genus Callicarpa are known to possess several medicinal effects. The constituents of the Taiwan endemic plant Callicarpa hypoleucophylla have never been studied. Therefore, C. hypoleucophylla was selected for our phytochemical investigation. Two new clerodane-type diterpenoids, named callihypolins A (1) and B (2), along with seven known compounds were isolated from the leaves and twigs of the Lamiaceae plant C. hypoleucophylla and then characterized. The structures of compounds 1 and 2 were elucidated by spectroscopic data analysis, specifically, two-dimension nuclear magnetic resonance (NMR). The anti-inflammatory activity of compounds 1–9 based on the suppression of superoxide anion generation and elastase release was evaluated. Among the isolates, compounds 2–4 showed anti-inflammatory activity (9.52−32.48% inhibition at the concentration 10 µm) by suppressing superoxide anion generation and elastase release. Our findings not only expand the description of the structural diversity of the compounds present in plants of the genus Callicarpa but also highlight the possibility of developing anti-inflammatory agents from Callicarpa endemic species.

Original languageEnglish
Article number2288
JournalMolecules
Volume25
Issue number10
DOIs
StatePublished - 05 2020

Bibliographical note

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Keywords

  • Anti-inflammatory activity
  • Callicarpa hypoleucophylla
  • Clerodane diterpenoid

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