Clincopathological characteristics and treatment outcomes of oral leukoplakia by carbon dioxide laser excision in the elderly patients

Shih Wei Yang; Yun Shien Lee; Liang Che Chang; Cheng Cheng Hwang; Tai An Chen

doi:10.1002/hed.26074

Clincopathological characteristics and treatment outcomes of oral leukoplakia by carbon dioxide laser excision in the elderly patients

Shih Wei Yang^*
, Yun Shien Lee
, Liang Che Chang
, Cheng Cheng Hwang
, Tai An Chen

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

10 Scopus citations

Abstract

Background: Older age is one of the factors associated with malignant transformation of oral leukoplakia (OL). The purpose of this study is to analyze the clincopathological features and treatment outcomes of OL in the elderly patients. Methods: The demographic data and histopathological results of the patients (age ≥ 65) who received carbon dioxide laser surgery for OL from 2002 to 2017 were analyzed statistically. Results: There were 53 males and 16 females, with a mean age 71.2 ± 4.9. The follow-up time was 42.5 ± 35.2 months. In the univariate analysis, morphology, pathology, and area were found to be factors associated with postoperative recurrence. Among these factors, pathology and area were the independent predictive factors for recurrence in the multivariate logistic regression model. Malignant transformation occurred in 8 of 69 patients (11.6%). Conclusions: The pathological high-risk dysplasia and area of OL were the two prognostic factors for postoperative recurrence.

Original language	English
Pages (from-to)	1014-1023
Number of pages	10
Journal	Head and Neck
Volume	42
Issue number	5
DOIs	https://doi.org/10.1002/hed.26074
State	Published - 01 05 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 The Authors. Head & Neck published by Wiley Periodicals, Inc.

Keywords

elderly
laser
malignant transformation
oral leukoplakia
recurrence

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10.1002/hed.26074

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@article{8d0423f4e4604f25b0539fef8794104c,

title = "Clincopathological characteristics and treatment outcomes of oral leukoplakia by carbon dioxide laser excision in the elderly patients",

abstract = "Background: Older age is one of the factors associated with malignant transformation of oral leukoplakia (OL). The purpose of this study is to analyze the clincopathological features and treatment outcomes of OL in the elderly patients. Methods: The demographic data and histopathological results of the patients (age ≥ 65) who received carbon dioxide laser surgery for OL from 2002 to 2017 were analyzed statistically. Results: There were 53 males and 16 females, with a mean age 71.2 ± 4.9. The follow-up time was 42.5 ± 35.2 months. In the univariate analysis, morphology, pathology, and area were found to be factors associated with postoperative recurrence. Among these factors, pathology and area were the independent predictive factors for recurrence in the multivariate logistic regression model. Malignant transformation occurred in 8 of 69 patients (11.6\%). Conclusions: The pathological high-risk dysplasia and area of OL were the two prognostic factors for postoperative recurrence.",

keywords = "elderly, laser, malignant transformation, oral leukoplakia, recurrence",

author = "Yang, \{Shih Wei\} and Lee, \{Yun Shien\} and Chang, \{Liang Che\} and Hwang, \{Cheng Cheng\} and Chen, \{Tai An\}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors. Head \& Neck published by Wiley Periodicals, Inc.",

year = "2020",

month = may,

day = "1",

doi = "10.1002/hed.26074",

language = "英语",

volume = "42",

pages = "1014--1023",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley \& Sons Inc.",

number = "5",

}

TY - JOUR

T1 - Clincopathological characteristics and treatment outcomes of oral leukoplakia by carbon dioxide laser excision in the elderly patients

AU - Yang, Shih Wei

AU - Lee, Yun Shien

AU - Chang, Liang Che

AU - Hwang, Cheng Cheng

AU - Chen, Tai An

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Background: Older age is one of the factors associated with malignant transformation of oral leukoplakia (OL). The purpose of this study is to analyze the clincopathological features and treatment outcomes of OL in the elderly patients. Methods: The demographic data and histopathological results of the patients (age ≥ 65) who received carbon dioxide laser surgery for OL from 2002 to 2017 were analyzed statistically. Results: There were 53 males and 16 females, with a mean age 71.2 ± 4.9. The follow-up time was 42.5 ± 35.2 months. In the univariate analysis, morphology, pathology, and area were found to be factors associated with postoperative recurrence. Among these factors, pathology and area were the independent predictive factors for recurrence in the multivariate logistic regression model. Malignant transformation occurred in 8 of 69 patients (11.6%). Conclusions: The pathological high-risk dysplasia and area of OL were the two prognostic factors for postoperative recurrence.

AB - Background: Older age is one of the factors associated with malignant transformation of oral leukoplakia (OL). The purpose of this study is to analyze the clincopathological features and treatment outcomes of OL in the elderly patients. Methods: The demographic data and histopathological results of the patients (age ≥ 65) who received carbon dioxide laser surgery for OL from 2002 to 2017 were analyzed statistically. Results: There were 53 males and 16 females, with a mean age 71.2 ± 4.9. The follow-up time was 42.5 ± 35.2 months. In the univariate analysis, morphology, pathology, and area were found to be factors associated with postoperative recurrence. Among these factors, pathology and area were the independent predictive factors for recurrence in the multivariate logistic regression model. Malignant transformation occurred in 8 of 69 patients (11.6%). Conclusions: The pathological high-risk dysplasia and area of OL were the two prognostic factors for postoperative recurrence.

KW - elderly

KW - laser

KW - malignant transformation

KW - oral leukoplakia

KW - recurrence

UR - https://www.scopus.com/pages/publications/85077845202

U2 - 10.1002/hed.26074

DO - 10.1002/hed.26074

M3 - 文章

C2 - 31930772

AN - SCOPUS:85077845202

SN - 1043-3074

VL - 42

SP - 1014

EP - 1023

JO - Head and Neck

JF - Head and Neck

IS - 5

ER -

Clincopathological characteristics and treatment outcomes of oral leukoplakia by carbon dioxide laser excision in the elderly patients

Abstract

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Keywords

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