Clinical and Histological Events Preceding Hepatitis B e Antigen Seroconversion in Chronic Type B Hepatitis

Yun Fan Liaw; Chia Ming Chu; Ih Jen Su; Miau Ju Huang; Deng Yn Lin; Chi Sin Chang-Chien

doi:10.1016/S0016-5085(83)80114-0

Clinical and Histological Events Preceding Hepatitis B e Antigen Seroconversion in Chronic Type B Hepatitis

Yun Fan Liaw^*, Chia Ming Chu, Ih Jen Su, Miau Ju Huang, Deng Yn Lin, Chi Sin Chang-Chien

^*Corresponding author for this work

Chang Gung Memorial Hospital

Research output: Contribution to journal › Journal Article › peer-review

326 Scopus citations

Abstract

A 60-mo longitudinal study has been undertaken in 99 HB_eAg-positive patients with clinicopathologically verified chronic hepatitis. Hepatitis B e antigen clearance occurred in 30 patients at a rate of ~ 17% per year. A phenomenon of abrupt elevation of serum glutamic pyruvic transaminase (>300 IU/L) with histological changes compatible with chronic lobular hepatitis was observed in 13 of 20 patients (65%) preceding spontaneous HB_eAg clearance. In contrast, 8 of 10 patients on immunosuppressive or antiviral therapy, or both, had uneventful HB_eAg clearance. It was concluded that HB_eAg clearance can occur in patients with varying immunologic status. The mechanism responsible for HB_eAg clearance awaits further study.

Original language	English
Pages (from-to)	216-219
Number of pages	4
Journal	Gastroenterology
Volume	84
Issue number	2
DOIs	https://doi.org/10.1016/S0016-5085(83)80114-0
State	Published - 1983
Externally published	Yes

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title = "Clinical and Histological Events Preceding Hepatitis B e Antigen Seroconversion in Chronic Type B Hepatitis",

abstract = "A 60-mo longitudinal study has been undertaken in 99 HBeAg-positive patients with clinicopathologically verified chronic hepatitis. Hepatitis B e antigen clearance occurred in 30 patients at a rate of ~ 17% per year. A phenomenon of abrupt elevation of serum glutamic pyruvic transaminase (>300 IU/L) with histological changes compatible with chronic lobular hepatitis was observed in 13 of 20 patients (65%) preceding spontaneous HBeAg clearance. In contrast, 8 of 10 patients on immunosuppressive or antiviral therapy, or both, had uneventful HBeAg clearance. It was concluded that HBeAg clearance can occur in patients with varying immunologic status. The mechanism responsible for HBeAg clearance awaits further study.",

author = "Liaw, {Yun Fan} and Chu, {Chia Ming} and Su, {Ih Jen} and Huang, {Miau Ju} and Lin, {Deng Yn} and Chang-Chien, {Chi Sin}",

year = "1983",

doi = "10.1016/S0016-5085(83)80114-0",

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volume = "84",

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T1 - Clinical and Histological Events Preceding Hepatitis B e Antigen Seroconversion in Chronic Type B Hepatitis

AU - Liaw, Yun Fan

AU - Chu, Chia Ming

AU - Su, Ih Jen

AU - Huang, Miau Ju

AU - Lin, Deng Yn

AU - Chang-Chien, Chi Sin

PY - 1983

Y1 - 1983

N2 - A 60-mo longitudinal study has been undertaken in 99 HBeAg-positive patients with clinicopathologically verified chronic hepatitis. Hepatitis B e antigen clearance occurred in 30 patients at a rate of ~ 17% per year. A phenomenon of abrupt elevation of serum glutamic pyruvic transaminase (>300 IU/L) with histological changes compatible with chronic lobular hepatitis was observed in 13 of 20 patients (65%) preceding spontaneous HBeAg clearance. In contrast, 8 of 10 patients on immunosuppressive or antiviral therapy, or both, had uneventful HBeAg clearance. It was concluded that HBeAg clearance can occur in patients with varying immunologic status. The mechanism responsible for HBeAg clearance awaits further study.

AB - A 60-mo longitudinal study has been undertaken in 99 HBeAg-positive patients with clinicopathologically verified chronic hepatitis. Hepatitis B e antigen clearance occurred in 30 patients at a rate of ~ 17% per year. A phenomenon of abrupt elevation of serum glutamic pyruvic transaminase (>300 IU/L) with histological changes compatible with chronic lobular hepatitis was observed in 13 of 20 patients (65%) preceding spontaneous HBeAg clearance. In contrast, 8 of 10 patients on immunosuppressive or antiviral therapy, or both, had uneventful HBeAg clearance. It was concluded that HBeAg clearance can occur in patients with varying immunologic status. The mechanism responsible for HBeAg clearance awaits further study.

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DO - 10.1016/S0016-5085(83)80114-0

M3 - 文章

C2 - 6848402

AN - SCOPUS:0020666891

SN - 0016-5085

VL - 84

SP - 216

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JO - Gastroenterology

JF - Gastroenterology

IS - 2

ER -

Clinical and Histological Events Preceding Hepatitis B e Antigen Seroconversion in Chronic Type B Hepatitis

Abstract

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