Clinical Characteristics of Eosinophilic Chronic Rhinosinusitis with Nasal Polyps in Adolescents

Chien Chia Huang, Po Hung Chang, Yen-Min Huang, Ta-Jen Lee, Chi Che Huang, Pei Wen Wu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

1 Scopus citations


Introduction: Eosinophilic chronic rhinosinusitis with nasal polyps (CRSwNP) is frequently associated with greater inflammation, poorer prognosis, and a high recurrence rate after sinus surgery. Objective: This study evaluated the clinical and imaging characteristics of eosinophilic CRSwNP in patients aged 12–17. Methods: We retrospectively enrolled 139 patients aged 12–17 with bilateral CRSwNP. Clinical characteristics, computed tomo-graphy (CT) features, tissue eosinophil counts, and eosinophil activity were evaluated. Results: Twenty-three (16.5%) patients had recurrent nasal polyps that required revision surgery. Patients requiring revision surgery had higher tissue eosinophil infiltration in the sinus mucosa than those not requiring revision surgery. The optimal cut-off value to distinguish the need for revision surgery was a tissue eosinophil count > 21.5/high-power field determined by the receiver operating characteristic curve. The Lund-Mackay and olfactory cleft opacification scores on CT images were significant predictors of tissue eosinophil count in the univariate analysis, and only olfactory opacification scores remained statistically significant in the multivariate analysis. Conclusion: This study revealed that the CT feature of the olfactory cleft opacification score could be a significant characteristic of eosinophilic CRSwNP in adolescents.

Original languageEnglish
Pages (from-to)1197-1206
Number of pages10
JournalJournal of Asthma and Allergy
StatePublished - 2023

Bibliographical note

Publisher Copyright:
© 2023 Huang et al. This work is published and licensed by Dove Medical Press Limited.


  • adolescent
  • chronic rhinosinusitis
  • computed tomography
  • eosinophil
  • nasal polyp


Dive into the research topics of 'Clinical Characteristics of Eosinophilic Chronic Rhinosinusitis with Nasal Polyps in Adolescents'. Together they form a unique fingerprint.

Cite this