TY - JOUR
T1 - Clinical characteristics of narrow-band imaging of oral erythroplakia and its correlation with pathology
AU - Yang, Shih Wei
AU - Lee, Yun Shien
AU - Chang, Liang Che
AU - Hwang, Cheng Cheng
AU - Luo, Cheng Ming
AU - Chen, Tai An
N1 - Publisher Copyright:
© 2015 Yang et al.; licensee BioMed Central.
PY - 2015/12/12
Y1 - 2015/12/12
N2 - Background: To analyze the clinical application of endoscope with narrow-band imaging (NBI) system in detecting high-grade dysplasia, carcinoma in situ, and carcinoma in oral erythroplakia. Methods: The demographic, histopathological data, and NBI vasculature architectures of patients receiving surgical intervention for oral erythroplakia were retrospectively reviewed and analyzed statistically. Results: A total of 72 patients, including 66 males and 6 females, with mean age of 54.6±11.2 years, were enrolled. The odds ratio of detecting high-grade dysplasia, carcinoma in situ, and carcinoma by twisted elongated morphology and destructive pattern of intraepithelial microvasculature was 15.46 (confidence interval 95 %: 3.81-72.84), and the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 80.95 %, 78.43 %, 60.71 %, 90.91 %, and 79.17 %, respectively, which were significantly better than other two established NBI criteria (p<0.001). Conclusions: Twisted, elongated, and destructive patterns of intraepithelial papillary capillary loop of NBI images are indicators for high-grade dysplasia, carcinoma in situ, and invasive carcinoma in oral erythroplakia.
AB - Background: To analyze the clinical application of endoscope with narrow-band imaging (NBI) system in detecting high-grade dysplasia, carcinoma in situ, and carcinoma in oral erythroplakia. Methods: The demographic, histopathological data, and NBI vasculature architectures of patients receiving surgical intervention for oral erythroplakia were retrospectively reviewed and analyzed statistically. Results: A total of 72 patients, including 66 males and 6 females, with mean age of 54.6±11.2 years, were enrolled. The odds ratio of detecting high-grade dysplasia, carcinoma in situ, and carcinoma by twisted elongated morphology and destructive pattern of intraepithelial microvasculature was 15.46 (confidence interval 95 %: 3.81-72.84), and the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 80.95 %, 78.43 %, 60.71 %, 90.91 %, and 79.17 %, respectively, which were significantly better than other two established NBI criteria (p<0.001). Conclusions: Twisted, elongated, and destructive patterns of intraepithelial papillary capillary loop of NBI images are indicators for high-grade dysplasia, carcinoma in situ, and invasive carcinoma in oral erythroplakia.
KW - Carcinoma
KW - Dysplasia
KW - Erythroplakia
KW - Narrow-band imaging
KW - Oral cavity
UR - http://www.scopus.com/inward/record.url?scp=85019175810&partnerID=8YFLogxK
U2 - 10.1186/s12885-015-1422-7
DO - 10.1186/s12885-015-1422-7
M3 - 文章
C2 - 25975717
AN - SCOPUS:85019175810
SN - 1471-2407
VL - 15
JO - BMC Cancer
JF - BMC Cancer
IS - 1
M1 - 406
ER -
