Clinical Effects of Botulinum Toxin A and Phenol Block on Gait in Children with Cerebral Palsy

Alice May-Kuen Wong*, Chia Ling Chen, Carl P.C. Chen, Shih Wei Chou, Chia Ying Chung, Max J.L. Chen

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

36 Scopus citations

Abstract

Objective: To compare the treatment effectiveness of botulinum toxin type A (BTX-A) and phenol blocks in managing lower limb spasticity and gait dysfunction in children with cerebral palsy. Design: This is a case-controlled study that took place in a tertiary center's gait laboratory. A total of 27 ambulatory children with cerebral palsy spastic diplegia, aged from 3 to 7 yrs, and 20 normal children were recruited into this study. Sixteen children with cerebral palsy received BTX-A injections, and 11 received phenol motor point blocks. Gait analyses were assessed by a portable computer-assisted system (Computer DynoGraphy, Infotronic, The Netherlands). Both the BTX-A and phenol groups received gait analysis at 1 wk before and 2 mos after injection treatments. Results: Significant improvements in gait variables of velocity and cadence were noted in children with cerebral palsy after BTX-A injections as compared with the phenol block group. Gaitline and cyclogram patterns also improved significantly in the BTX-A group. The adverse clinical effects of BTX-A injections were less severe as compared with phenol injections. Conclusions: BTX-A injections demonstrated superior treatment effects in improving gait variables and patterns in children with spastic diplegia as compared with phenol blocks. BTX-A injections also revealed fewer clinical side effects and were well tolerated by children with cerebral palsies.

Original languageEnglish
Pages (from-to)284-291
Number of pages8
JournalAmerican Journal of Physical Medicine and Rehabilitation
Volume83
Issue number4
DOIs
StatePublished - 04 2004

Keywords

  • Botulinum toxin type A
  • Cerebral palsy
  • Gait
  • Phenol block
  • Spasticity

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