TY - JOUR
T1 - Clinical nodal stage is a significant predictor of outcome in patients with oral cavity squamous cell carcinoma and pathologically negative neck metastases
T2 - Results of the international consortium for outcome research
AU - Amit, M.
AU - Yen, T. C.
AU - Liao, C. T.
AU - Binenbaum, Y.
AU - Chaturvedi, P.
AU - Agarwal, J. P.
AU - Kowalski, L. P.
AU - Ebrahimi, A.
AU - Clark, J. R.
AU - Cernea, C. R.
AU - Brandao, S. J.
AU - Kreppel, M.
AU - Zöller, J.
AU - Fliss, D.
AU - Bachar, G.
AU - Shpitzer, T.
AU - Bolzoni, V. A.
AU - Patel, P. R.
AU - Jonnalagadda, S.
AU - Robbins, K. T.
AU - Shah, J. P.
AU - Patel, S. G.
AU - Gil, Ziv
PY - 2013/10
Y1 - 2013/10
N2 - Background: We aimed to study the importance of clinical N classification (cN) in a subgroup of patients with oral cavity squamous cell carcinoma (OSCC) and pathologically negative neck nodes (pN-). Methods: A total of 2,258 patients from 11 cancer centers who underwent neck dissection for OSCC (1990-2011) had pN- disease. The median follow-up was 44 months. 5-year overall survival (OS), disease-specific survival (DSS), disease free survival, local control, locoregional control, and distant metastasis rates were calculated by the Kaplan-Meier method. cN classification and tumor, node, metastasis classification system staging variables were subjected to multivariate analysis. Results: A total of 345 patients were preoperatively classified as cN+ and 1,913 were classified as cN-. The 5-year OS and DSS of cN- patients were 73.6 and 82.2 %, respectively. The 5-year OS and DSS of cN+ patients were 64.9 and 76.9 %, respectively (p < 0.0001 each). A cN+ classification was a significant predictor of worse OS (p = 0.03) and DSS (p = 0.016), regardless of treatment, depth of invasion, or extent of neck dissection. cN classification was associated with recurrence-free survival (p = 0.01) and locoregional (neck and primary tumor) control (p = 0.004), but not with local (p = 0.19) and distant (p = 0.06) recurrence rates. Conclusions: Clinical evidence of neck metastases is an independent predictor of outcome, even in patients with pN- nodes.
AB - Background: We aimed to study the importance of clinical N classification (cN) in a subgroup of patients with oral cavity squamous cell carcinoma (OSCC) and pathologically negative neck nodes (pN-). Methods: A total of 2,258 patients from 11 cancer centers who underwent neck dissection for OSCC (1990-2011) had pN- disease. The median follow-up was 44 months. 5-year overall survival (OS), disease-specific survival (DSS), disease free survival, local control, locoregional control, and distant metastasis rates were calculated by the Kaplan-Meier method. cN classification and tumor, node, metastasis classification system staging variables were subjected to multivariate analysis. Results: A total of 345 patients were preoperatively classified as cN+ and 1,913 were classified as cN-. The 5-year OS and DSS of cN- patients were 73.6 and 82.2 %, respectively. The 5-year OS and DSS of cN+ patients were 64.9 and 76.9 %, respectively (p < 0.0001 each). A cN+ classification was a significant predictor of worse OS (p = 0.03) and DSS (p = 0.016), regardless of treatment, depth of invasion, or extent of neck dissection. cN classification was associated with recurrence-free survival (p = 0.01) and locoregional (neck and primary tumor) control (p = 0.004), but not with local (p = 0.19) and distant (p = 0.06) recurrence rates. Conclusions: Clinical evidence of neck metastases is an independent predictor of outcome, even in patients with pN- nodes.
UR - https://www.scopus.com/pages/publications/84883814297
U2 - 10.1245/s10434-013-3044-0
DO - 10.1245/s10434-013-3044-0
M3 - 文章
C2 - 23775408
AN - SCOPUS:84883814297
SN - 1068-9265
VL - 20
SP - 3575
EP - 3581
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
IS - 11
ER -
