Clinical outcomes of traditional Chinese medicine compound formula in treating sleep-disordered breathing patients

Yi Hong Wu*, Yi Chia Wei, Yu Shan Tai, Kuan Jen Chen, Hsueh Yu Li

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

9 Scopus citations


Sleep-Disordered Breathing (SDB) is a prevalent affliction, which can range from simple snoring to severely obstructive sleep apnea. Compared to current treatment options of SDB, traditional Chinese medicine (TCM) provides a noninvasive way to relieve SDB-related symptoms and deaths. The purpose of this retrospective study was to observe the progression of adult SDB patients who had taken compound formula SZ + NUH (concentrated herbal granules) for four weeks. Depending on subjects' individual needs, minor additions of formulas or single herbs were allowed. We found a significant amount of relief from snoring among the 118 enrolled subjects, according to before-after scores observed through the Snore OutcomeSurvey (SOS). Furthermore, as projected from the moderate linear correlation in before-after scores, we inferred that those cases with more severe snoring at baseline had greater improvement after treatment. Excessive daytime sleepiness was also significantly improved according to the results of the Epworth Sleepiness Scale (ESS). Assessment, using the SF-36 (Taiwanese version) revealed possible benefits of SZ + NUH in improving multiple facets of subjects' quality of life. During treatment, no significant side effects occurred. In conclusion, the TCM compound formula based on SZ + NUH could be a safe and effective option for SDB treatment.

Original languageEnglish
Pages (from-to)11-24
Number of pages14
JournalAmerican Journal of Chinese Medicine
Issue number1
StatePublished - 2012


  • Excessive Daytime Sleepiness
  • Herbs
  • Obstructive Sleep Apnea
  • Sleep-Disordered Breathing
  • Snoring
  • Traditional Chinese Medicine


Dive into the research topics of 'Clinical outcomes of traditional Chinese medicine compound formula in treating sleep-disordered breathing patients'. Together they form a unique fingerprint.

Cite this