Clinical value of 18F-FDG PET/CT in detecting adrenal metastasis in patients with Hepatocellular carcinoma

Yin Lin, Long Bin Jeng, Hsin Yi Wang, Shih Chuan Tsai, Wan Yu Lin, Chia Hung Kao*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

3 Scopus citations


The purpose of this study was to evaluate the accuracy of 18F-FDG PET/CT scans in detecting adrenal metastasis in liver transplant candidates with hepatocellular carcinoma (HCC). A total of 166 patients diagnosed with HCC received 18F-FDG PET/CT imaging before liver transplantation. Of these patients, 5 patients (4 males, 1 female; median age: 51.2 y, range: 33-61 y) were found to have suspected adrenal metastases and were included in this study. Two cases (Cases 1 and 5) underwent an 18F-FDG PET/CT scan at the initial stage, 3 cases (Cases 2-4) underwent an 18F-FDG PET/CT scan for restaging, and one case (Case 5) underwent a second 18F-FDG PET/CT scan for evaluating treatment response. Among the 8 lesions, there was one false-negative metastatic lesion (Lesion 4, Case 3) and one false-positive adrenal gland lesion (Lesion 7, Case 5) when compared with either histopathologic reports or established clinical and imaging follow-up results. In general, 18F-FDG PET/CT scans have limitations that make it difficult to distinguish between malignant and benign lesions in adrenal glands that are based only on quantitative values measured using the 18F-FDG PET/CT scan.

Original languageEnglish
Pages (from-to)593-599
Number of pages7
JournalTechnology in Cancer Research and Treatment
Issue number5
StatePublished - 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© SAGE Publications Inc. 2014.


  • Adrenal metastasis
  • Liver transplantation
  • References


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