Clinicopathologic analysis of renal epithelioid angiomyolipoma: Consecutively excised 23 cases

Han Yu Tsai, Kun Han Lee, Kwai Fong Ng, Yu Ting Kao, Cheng Keng Chuang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

12 Scopus citations


Renal epithelioid angiomyolipoma (eAML) is considered a malignant variant of angiomyolipoma (AML). From 2001 to 2016, a total of 570 patients were diagnosed with renal AML in Linko Chang GungMemorial Hospital, Taiwan, including 23 cases of renal eAML. All 23 eAML cases were made up of at least 10% of epithelioid cells histologically. Three of these cases were found with multiple tumors. Two cases developed distant metastasis: one had mediastinal lymph nodes and bilateral lung metastasis; the other one had tumor recurrence over liver and retroperitoneum 1 year after radical nephrectomy. They were then divided into invasive (n = 5) and noninvasive (n = 18) groups according to their clinical behavior. The invasive group showed more severe nuclear atypia and higher rates in tumor necrosis. There was statistically no significance in relation to a patient's age, tumor size, and mitotic count between two groups. After conducting a series of studies, we suggest treating eAML with the guideline of renal cell carcinoma.

Original languageEnglish
Pages (from-to)33-38
Number of pages6
JournalKaohsiung Journal of Medical Sciences
Issue number1
StatePublished - 01 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 The Authors.


  • Renal cell carcinoma
  • Renal epithelioid angiomyolipoma
  • Renal tumor
  • Tuberous sclerosis complex


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