Clinicopathological characteristics and outcomes in stage I-III mucinous gastric adenocarcinoma: A retrospective study at a single medical center

Jun Te Hsu*, Chen Wei Wang, Puo Hsien Le, Ren Chin Wu, Tsung Hsing Chen, Kun Chun Chiang, Chun Jung Lin, Ta Sen Yeh

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

10 Scopus citations

Abstract

Background: The clinicopathological characteristics and outcomes of mucinous gastric adenocarcinoma (GC) remain unclear. We report the clinicopathological features and prognosis of patients with mucinous histology who underwent radical-intent gastrectomy. Methods: We reviewed the medical records of 1470 patients with pathologically proven undifferentiated GC undergoing radical-intent gastrectomy between 1995 and 2007. The patients were stratified into three groups according to their histological type: mucinous carcinoma (MC), signet ring cell carcinoma (SRCC), and poorly differentiated carcinoma (PDC). Clinicopathological factors affecting prognosis were collected prospectively and analyzed. Results: In stage III MC, the age and size were significantly greater and larger than in SRCC and PDC; a lower proportion of perineural invasion was identified in MC, and female predominance was noted in SRCC in comparison with MC and PDC. The cumulative overall survival rates of stage I-III GC patients with MC were significantly superior compared to those with PDC, but not SRCC. Stage III GC patients with MC had a better prognosis than those with SRCC or PDC; the difference in survival was not evident in stages I or II. Conclusions: Thus, MC presents with different clinicopathological features and prognosis from SRCC and PDC. The patients with stage III gastric MC had favorable outcomes.

Original languageEnglish
Article number123
JournalWorld Journal of Surgical Oncology
Volume14
Issue number1
DOIs
StatePublished - 2016

Bibliographical note

Publisher Copyright:
© 2016 Hsu et al.

Keywords

  • Mucinous gastric cancer
  • Prognostic factor
  • Undifferentiated

Fingerprint

Dive into the research topics of 'Clinicopathological characteristics and outcomes in stage I-III mucinous gastric adenocarcinoma: A retrospective study at a single medical center'. Together they form a unique fingerprint.

Cite this