Abstract
In chloralose-urethane-anesthetized cats, intravertebral injection of clonidine (0.5-4.0 μ/kg) elicited a drastic suppression of the bradycardia induced by stimulating the gigantocellular reticular nucleus (GRN). The degree of blockage of GRN-induced cardioinhibition was related to the time course of the inherent cardiovascular effects of clonidine. It was also dependent upon the dose of the imidazoline compound and the intensity/train pulse frequency of reticular stimulation. It was suggested that the two mechanisms may interact with one another in the brainstem and possible modes of interaction were discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 393-396 |
| Number of pages | 4 |
| Journal | European Journal of Pharmacology |
| Volume | 61 |
| Issue number | 4 |
| DOIs | |
| State | Published - 22 02 1980 |
| Externally published | Yes |
Keywords
- Bradycardia
- Cat
- Clonidine
- Gigantocellular reticular nucleus
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