Cognitive function variations in postmenopausal women treated with continuous, combined HRT or tibolone: A comparison

Hsien An Pan, Shan Tair Wang, Ming Chyi Pai, Chih Hung Chen, Meng Hsing Wu, Ko En Huang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

16 Scopus citations


OBJECTIVE: To compare cognitive function in postmenopausal women receiving continuous hormone replacement therapy and those receiving tibolone. STUDY DESIGN: This was a 6-month, prospective, single-blind, single center, randomized study. A total of 50 healthy, postmenopausal women were enrolled. In the end, 40 women completed the 6-month follow-up. One group (23 subjects) received conjugated equine estrogens (CEE), 0.625 mg/d, and medroxyprogesterone acetate (MPA), 5 mg/d. The other group (17 subjects) received tibolone, 2.5 mg/d. Their serum estradiol levels and Cognitive Abilities Screening Instrument (CASI) and Mini-Mental State Examination (MMSE) scores were obtained before starting and after 3 and 6 months of treatment. RESULTS: There was a significant increase in the serum estradiol level in the CEE + MPA group, especially after 3 months of treatment, but there was no increase in the estradiol level in the tibolone group. The CASI and MMSE scores of the CEE + MPA group and the tibolone group after 3 and 6 months of treatment showed no significant difference between the two groups apart from the MMSE at the 3-month follow-up. We saw an increasing trend in CASI and MMSE scores after treatment in both groups; however, the increases were not statistically significant. The rate of increase of both CASI and MMSE scores in the CEE + MPA group was greater than in the tibolone group, though the difference was not significant. CONCLUSION: This preliminary study demonstrated that both CEE + MPA and tibolone can preserve cognitive function and may be able to prevent cognitive decline in postmenopausal women during short-term treatment. Our results also show that continuous, combined CEE + MPA seems to be marginally more effective than tibolone in improving cognitive processes; however, long-term study is needed to follow-up such effect.

Original languageEnglish
Pages (from-to)375-380
Number of pages6
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number5
StatePublished - 01 05 2003
Externally publishedYes


  • Cognitive function
  • Hormone replacement therapy
  • Menopause
  • Tibolone


Dive into the research topics of 'Cognitive function variations in postmenopausal women treated with continuous, combined HRT or tibolone: A comparison'. Together they form a unique fingerprint.

Cite this