Colistin resistance mechanisms in Klebsiella pneumoniae strains from Taiwan

Yi Hsiang Cheng; Tzu Lung Lin; Yi Jiun Pan; Yu Ping Wang; Yi Tsung Lin; Jin Town Wang

doi:10.1128/AAC.04763-14

Colistin resistance mechanisms in Klebsiella pneumoniae strains from Taiwan

Yi Hsiang Cheng, Tzu Lung Lin, Yi Jiun Pan, Yu Ping Wang, Yi Tsung Lin, Jin Town Wang

Research output: Contribution to journal › Journal Article › peer-review

137 Scopus citations

Abstract

Colistin is one of the antibiotics of last resort for the treatment of carbapenem-resistant Klebsiella pneumoniae infection. This study showed that capsular type K64 (50%) and ST11 (53.9%) are the prevalent capsular and sequence types in the colistin-resistant strains in Taiwan. The interruption of transcripts (38.5%) and amino acid mutation (15.4%) in mgrB are the major mechanisms contributing to colistin resistance. In addition, novel single amino acid changes in MgrB (Stop48Tyr) and PhoQ (Leu26Pro) were observed to contribute to colistin resistance.

Original language	English
Pages (from-to)	2909-2913
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	59
Issue number	5
DOIs	https://doi.org/10.1128/AAC.04763-14
State	Published - 01 05 2015
Externally published	Yes

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Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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abstract = "Colistin is one of the antibiotics of last resort for the treatment of carbapenem-resistant Klebsiella pneumoniae infection. This study showed that capsular type K64 (50%) and ST11 (53.9%) are the prevalent capsular and sequence types in the colistin-resistant strains in Taiwan. The interruption of transcripts (38.5%) and amino acid mutation (15.4%) in mgrB are the major mechanisms contributing to colistin resistance. In addition, novel single amino acid changes in MgrB (Stop48Tyr) and PhoQ (Leu26Pro) were observed to contribute to colistin resistance.",

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AU - Pan, Yi Jiun

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AU - Lin, Yi Tsung

AU - Wang, Jin Town

PY - 2015/5/1

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AB - Colistin is one of the antibiotics of last resort for the treatment of carbapenem-resistant Klebsiella pneumoniae infection. This study showed that capsular type K64 (50%) and ST11 (53.9%) are the prevalent capsular and sequence types in the colistin-resistant strains in Taiwan. The interruption of transcripts (38.5%) and amino acid mutation (15.4%) in mgrB are the major mechanisms contributing to colistin resistance. In addition, novel single amino acid changes in MgrB (Stop48Tyr) and PhoQ (Leu26Pro) were observed to contribute to colistin resistance.

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Colistin resistance mechanisms in Klebsiella pneumoniae strains from Taiwan

Abstract

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