Colistin resistance mechanisms in Klebsiella pneumoniae strains from Taiwan

Yi Hsiang Cheng, Tzu Lung Lin, Yi Jiun Pan, Yu Ping Wang, Yi Tsung Lin, Jin Town Wang

Research output: Contribution to journalJournal Article peer-review

126 Scopus citations

Abstract

Colistin is one of the antibiotics of last resort for the treatment of carbapenem-resistant Klebsiella pneumoniae infection. This study showed that capsular type K64 (50%) and ST11 (53.9%) are the prevalent capsular and sequence types in the colistin-resistant strains in Taiwan. The interruption of transcripts (38.5%) and amino acid mutation (15.4%) in mgrB are the major mechanisms contributing to colistin resistance. In addition, novel single amino acid changes in MgrB (Stop48Tyr) and PhoQ (Leu26Pro) were observed to contribute to colistin resistance.

Original languageEnglish
Pages (from-to)2909-2913
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume59
Issue number5
DOIs
StatePublished - 01 05 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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