Collagen-grafted temperature-responsive nonwoven fabric for wound dressing

Jyh Ping Chen; Wen Li Lee

doi:10.1016/j.apsusc.2008.06.111

Collagen-grafted temperature-responsive nonwoven fabric for wound dressing

Jyh Ping Chen^*, Wen Li Lee

^*Corresponding author for this work

Department of Chemical and Materials Engineering

Chang Gung University

Research output: Contribution to journal › Journal Article › peer-review

25 Scopus citations

Abstract

Polypropylene (PP) nonwoven fabric (NWF) was modified by direct current pulsed plasma followed by grafting with acrylic acid (AAc) to improve its surface hydrophilicity and to introduce carboxylic acid group on the surface for further conjugation with bioactive collagen biomolecule. To endow temperature-responsive property, PP-g-collagen NWF was further modified with poly(N-isopropylacrylamide) (PNIPAAm). Experimental results demonstrated that the amount of AAc and collagen grafted were 43.4 nmole/cm ² , and 35.9 μg/cm ² , respectively. The amount of PNIPAAm immobilized was 213 μg/cm ² . The physical properties, surface chemical composition, and microstructure of the NWFs were characterized. From animal study, modified NWFs were found to promote wound healing with bigraft PP-g-collagen-g-PNIPAAm NWF showing the best performance.

Original language	English
Pages (from-to)	412-415
Number of pages	4
Journal	Applied Surface Science
Volume	255
Issue number	2
DOIs	https://doi.org/10.1016/j.apsusc.2008.06.111
State	Published - 15 11 2008

Keywords

Collagen
Nonwoven
Plasma modification
Wound dressing

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10.1016/j.apsusc.2008.06.111

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title = "Collagen-grafted temperature-responsive nonwoven fabric for wound dressing",

abstract = " Polypropylene (PP) nonwoven fabric (NWF) was modified by direct current pulsed plasma followed by grafting with acrylic acid (AAc) to improve its surface hydrophilicity and to introduce carboxylic acid group on the surface for further conjugation with bioactive collagen biomolecule. To endow temperature-responsive property, PP-g-collagen NWF was further modified with poly(N-isopropylacrylamide) (PNIPAAm). Experimental results demonstrated that the amount of AAc and collagen grafted were 43.4 nmole/cm 2 , and 35.9 μg/cm 2 , respectively. The amount of PNIPAAm immobilized was 213 μg/cm 2 . The physical properties, surface chemical composition, and microstructure of the NWFs were characterized. From animal study, modified NWFs were found to promote wound healing with bigraft PP-g-collagen-g-PNIPAAm NWF showing the best performance.",

keywords = "Collagen, Nonwoven, Plasma modification, Wound dressing",

author = "Chen, \{Jyh Ping\} and Lee, \{Wen Li\}",

year = "2008",

month = nov,

day = "15",

doi = "10.1016/j.apsusc.2008.06.111",

language = "英语",

volume = "255",

pages = "412--415",

journal = "Applied Surface Science",

issn = "0169-4332",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Collagen-grafted temperature-responsive nonwoven fabric for wound dressing

AU - Chen, Jyh Ping

AU - Lee, Wen Li

PY - 2008/11/15

Y1 - 2008/11/15

N2 - Polypropylene (PP) nonwoven fabric (NWF) was modified by direct current pulsed plasma followed by grafting with acrylic acid (AAc) to improve its surface hydrophilicity and to introduce carboxylic acid group on the surface for further conjugation with bioactive collagen biomolecule. To endow temperature-responsive property, PP-g-collagen NWF was further modified with poly(N-isopropylacrylamide) (PNIPAAm). Experimental results demonstrated that the amount of AAc and collagen grafted were 43.4 nmole/cm 2 , and 35.9 μg/cm 2 , respectively. The amount of PNIPAAm immobilized was 213 μg/cm 2 . The physical properties, surface chemical composition, and microstructure of the NWFs were characterized. From animal study, modified NWFs were found to promote wound healing with bigraft PP-g-collagen-g-PNIPAAm NWF showing the best performance.

AB - Polypropylene (PP) nonwoven fabric (NWF) was modified by direct current pulsed plasma followed by grafting with acrylic acid (AAc) to improve its surface hydrophilicity and to introduce carboxylic acid group on the surface for further conjugation with bioactive collagen biomolecule. To endow temperature-responsive property, PP-g-collagen NWF was further modified with poly(N-isopropylacrylamide) (PNIPAAm). Experimental results demonstrated that the amount of AAc and collagen grafted were 43.4 nmole/cm 2 , and 35.9 μg/cm 2 , respectively. The amount of PNIPAAm immobilized was 213 μg/cm 2 . The physical properties, surface chemical composition, and microstructure of the NWFs were characterized. From animal study, modified NWFs were found to promote wound healing with bigraft PP-g-collagen-g-PNIPAAm NWF showing the best performance.

KW - Collagen

KW - Nonwoven

KW - Plasma modification

KW - Wound dressing

UR - https://www.scopus.com/pages/publications/54349093497

U2 - 10.1016/j.apsusc.2008.06.111

DO - 10.1016/j.apsusc.2008.06.111

M3 - 文章

AN - SCOPUS:54349093497

SN - 0169-4332

VL - 255

SP - 412

EP - 415

JO - Applied Surface Science

JF - Applied Surface Science

IS - 2

ER -

Collagen-grafted temperature-responsive nonwoven fabric for wound dressing

Abstract

Keywords

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