Colon carcinoma with synchronous ovarian metastasis - Report and discussion of five cases

Tsai Shen Yang*, Kuan Cheng Hsu, Reiping Tang, Ting Chang Chang

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

5 Scopus citations


Ovarian metastasis may present at the time of initial diagnosis of colon carcinoma or as a later recurrence. Little meaningful information is available regarding the treatment and outcome of synchronous ovarian metastasis of colon carcinoma. This report describes the clinical course of five patients with synchronous ovarian metastasis of colon carcinoma who were treated with aggressive surgery and chemotherapy. The treatment consisted of maximal surgical debulking followed by systemic chemotherapy with weekly 24 h infusion of high-dose 5-fluorouracil and leucovorin. All of the five patients had subsequent disease-free periods ranging from 6 to 43+ months following operation. Two of the patients who had no or minimal peritoneal involvement were still alive without disease at 33 and 43 months. The data from these cases suggest that aggressive surgery and systemic chemotherapy may be highly efficacious in the treatment of colon carcinoma with synchronous ovarian metastasis. Maximal debulking followed by chemotherapy may be particularly effective in those patients with minimal peritoneal involvement. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)279-283
Number of pages5
JournalAnti-Cancer Drugs
Issue number4
StatePublished - 2000
Externally publishedYes


  • Colon carcinoma
  • Debulking surgery
  • Postoperative chemotherapy
  • Synchronous ovarian metastasis


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