Combination of CTLA-4 and TGFβ1 gene polymorphisms associated with dengue hemorrhagic fever and virus load in a dengue-2 outbreak

Rong Fu Chen; Lin Wang; Jiin Tsuey Cheng; Hau Chuang; Jen Chieh Chang; Jien Wei Liu; I. Chun Lin; Kuender D. Yang

doi:10.1016/j.clim.2009.01.015

Combination of CTLA-4 and TGFβ1 gene polymorphisms associated with dengue hemorrhagic fever and virus load in a dengue-2 outbreak

Rong Fu Chen, Lin Wang, Jiin Tsuey Cheng, Hau Chuang, Jen Chieh Chang, Jien Wei Liu, I. Chun Lin, Kuender D. Yang^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

39 Scopus citations

Abstract

The pathogenesis of dengue hemorrhagic fever (DHF) has been considered to be massive immune activation of T cells. Abnormal expression of the immune regulatory molecules, CTLA-4 and TGFβ1, leads to disturbances of regulatory T cell immune response. We investigate the contribution of CTLA-4 and TGFβ1 in DHF by analyzing them for association with virus load in blood and polymorphisms of CTLA-4 +49A/G, and TGFβ1 -509C/T in a DEN-2 outbreak. The increased frequency of the TGFβ1 -509 CC genotype in patients with DHF was compared to those with dengue fever (OR = 1.9, p = 0.034). Moreover, the presence of the CTLA-4 +49 G allele and TGFβ1 -509 CC genotype increased the susceptibility to risk of DHF (OR = 2.1, p = 0.028) and significantly higher virus load (p = 0.013). This finding suggests that a combination of CTLA-4 and TGFβ1 polymorphisms is associated with the susceptibility of DHF and higher virus load. Crown

Original language	English
Pages (from-to)	404-409
Number of pages	6
Journal	Clinical Immunology
Volume	131
Issue number	3
DOIs	https://doi.org/10.1016/j.clim.2009.01.015
State	Published - 06 2009

Keywords

CTLA-4
DHF
Polymorphisms
TGFβ1
Virus load

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.clim.2009.01.015

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@article{f794aa328065449582a1ed8a2842f370,

title = "Combination of CTLA-4 and TGFβ1 gene polymorphisms associated with dengue hemorrhagic fever and virus load in a dengue-2 outbreak",

abstract = "The pathogenesis of dengue hemorrhagic fever (DHF) has been considered to be massive immune activation of T cells. Abnormal expression of the immune regulatory molecules, CTLA-4 and TGFβ1, leads to disturbances of regulatory T cell immune response. We investigate the contribution of CTLA-4 and TGFβ1 in DHF by analyzing them for association with virus load in blood and polymorphisms of CTLA-4 +49A/G, and TGFβ1 -509C/T in a DEN-2 outbreak. The increased frequency of the TGFβ1 -509 CC genotype in patients with DHF was compared to those with dengue fever (OR = 1.9, p = 0.034). Moreover, the presence of the CTLA-4 +49 G allele and TGFβ1 -509 CC genotype increased the susceptibility to risk of DHF (OR = 2.1, p = 0.028) and significantly higher virus load (p = 0.013). This finding suggests that a combination of CTLA-4 and TGFβ1 polymorphisms is associated with the susceptibility of DHF and higher virus load. Crown",

keywords = "CTLA-4, DHF, Polymorphisms, TGFβ1, Virus load",

author = "Chen, {Rong Fu} and Lin Wang and Cheng, {Jiin Tsuey} and Hau Chuang and Chang, {Jen Chieh} and Liu, {Jien Wei} and Lin, {I. Chun} and Yang, {Kuender D.}",

year = "2009",

month = jun,

doi = "10.1016/j.clim.2009.01.015",

language = "英语",

volume = "131",

pages = "404--409",

journal = "Clinical Immunology",

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T1 - Combination of CTLA-4 and TGFβ1 gene polymorphisms associated with dengue hemorrhagic fever and virus load in a dengue-2 outbreak

AU - Chen, Rong Fu

AU - Wang, Lin

AU - Cheng, Jiin Tsuey

AU - Chuang, Hau

AU - Chang, Jen Chieh

AU - Liu, Jien Wei

AU - Lin, I. Chun

AU - Yang, Kuender D.

PY - 2009/6

Y1 - 2009/6

N2 - The pathogenesis of dengue hemorrhagic fever (DHF) has been considered to be massive immune activation of T cells. Abnormal expression of the immune regulatory molecules, CTLA-4 and TGFβ1, leads to disturbances of regulatory T cell immune response. We investigate the contribution of CTLA-4 and TGFβ1 in DHF by analyzing them for association with virus load in blood and polymorphisms of CTLA-4 +49A/G, and TGFβ1 -509C/T in a DEN-2 outbreak. The increased frequency of the TGFβ1 -509 CC genotype in patients with DHF was compared to those with dengue fever (OR = 1.9, p = 0.034). Moreover, the presence of the CTLA-4 +49 G allele and TGFβ1 -509 CC genotype increased the susceptibility to risk of DHF (OR = 2.1, p = 0.028) and significantly higher virus load (p = 0.013). This finding suggests that a combination of CTLA-4 and TGFβ1 polymorphisms is associated with the susceptibility of DHF and higher virus load. Crown

AB - The pathogenesis of dengue hemorrhagic fever (DHF) has been considered to be massive immune activation of T cells. Abnormal expression of the immune regulatory molecules, CTLA-4 and TGFβ1, leads to disturbances of regulatory T cell immune response. We investigate the contribution of CTLA-4 and TGFβ1 in DHF by analyzing them for association with virus load in blood and polymorphisms of CTLA-4 +49A/G, and TGFβ1 -509C/T in a DEN-2 outbreak. The increased frequency of the TGFβ1 -509 CC genotype in patients with DHF was compared to those with dengue fever (OR = 1.9, p = 0.034). Moreover, the presence of the CTLA-4 +49 G allele and TGFβ1 -509 CC genotype increased the susceptibility to risk of DHF (OR = 2.1, p = 0.028) and significantly higher virus load (p = 0.013). This finding suggests that a combination of CTLA-4 and TGFβ1 polymorphisms is associated with the susceptibility of DHF and higher virus load. Crown

KW - CTLA-4

KW - DHF

KW - Polymorphisms

KW - TGFβ1

KW - Virus load

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U2 - 10.1016/j.clim.2009.01.015

DO - 10.1016/j.clim.2009.01.015

M3 - 文章

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AN - SCOPUS:67349196789

SN - 1521-6616

VL - 131

SP - 404

EP - 409

JO - Clinical Immunology

JF - Clinical Immunology

IS - 3

ER -

Combination of CTLA-4 and TGFβ1 gene polymorphisms associated with dengue hemorrhagic fever and virus load in a dengue-2 outbreak

Abstract

Keywords

UN SDGs

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