Combined Initial Cyclophosphamide with Repeated Methylprednisolone Pulse Therapy for Severe Paraquat Poisoning from Dermal Exposure

Nan Chieh Lin, Ja Liang Lin*, Dan Tzu Lin-Tan, Chun Chen Yu

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

27 Scopus citations

Abstract

The article presents a patient with severe paraquat poisoning from dermal exposure, who had chemical bums to more than 10% of his body surface area, serum paraquat level 0.13 μg/mL 60 hr after exposure, and severe hypoxemia (PaO2 41.6 mmHg). The patient was successfully treated with combined initial megadoses of cyclophosphamide (15 mg/kg/day, total 2 days) with repeated methylprednisolone pulse therapy (15 mg/kg/day, total 6 days) and continuous dexamethasone administration (5 mg every 8 hr), and recovered completely without sequelae 3 months later. This treatment deserves further investigation in future clinical trials.

Original languageEnglish
Pages (from-to)877-881
Number of pages5
JournalJournal of Toxicology - Clinical Toxicology
Volume41
Issue number6
DOIs
StatePublished - 2003
Externally publishedYes

Keywords

  • Cyclophosphamide
  • Dermal Exposure
  • Dexamethasone
  • Methylprednisolone pulse therapy
  • Paraquat poisoning

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