Abstract
The article presents a patient with severe paraquat poisoning from dermal exposure, who had chemical bums to more than 10% of his body surface area, serum paraquat level 0.13 μg/mL 60 hr after exposure, and severe hypoxemia (PaO2 41.6 mmHg). The patient was successfully treated with combined initial megadoses of cyclophosphamide (15 mg/kg/day, total 2 days) with repeated methylprednisolone pulse therapy (15 mg/kg/day, total 6 days) and continuous dexamethasone administration (5 mg every 8 hr), and recovered completely without sequelae 3 months later. This treatment deserves further investigation in future clinical trials.
Original language | English |
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Pages (from-to) | 877-881 |
Number of pages | 5 |
Journal | Journal of Toxicology - Clinical Toxicology |
Volume | 41 |
Issue number | 6 |
DOIs | |
State | Published - 2003 |
Externally published | Yes |
Keywords
- Cyclophosphamide
- Dermal Exposure
- Dexamethasone
- Methylprednisolone pulse therapy
- Paraquat poisoning