Combined use of esmolol and nicardipine to blunt the haemodynamic changes following laryngoscopy and tracheal intubation

P. H. Tan; L. C. Yang; H. C. Shih; C. R. Lin; K. C. Lan; C. S. Chen

doi:10.1046/j.1365-2044.2002.02624_4.x

Combined use of esmolol and nicardipine to blunt the haemodynamic changes following laryngoscopy and tracheal intubation

P. H. Tan^*, L. C. Yang, H. C. Shih, C. R. Lin, K. C. Lan, C. S. Chen

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

30 Scopus citations

Abstract

We examined the effect of different combinations of esmolol and nicardipine upon the circulatory response to tracheal intubation. One hundred patients were randomly allocated into five groups of twenty to receive pretreatments of saline or different combinations of esmolol (0.5 or 1.0 mg.kg^-1) and nicardipine (15 or 30 μg.kg^-1). Significant tachycardia persisted over a 5-min period after intubation in all five groups compared with baseline levels (p < 0.05). Patients receiving esmolol 1.0 mg.kg^-1 and nicardipine 30 μg.kg^-1 showed no significant change in systolic blood pressure after tracheal intubation compared with baseline and significant lower peak systolic blood pressure than those receiving saline (p = 0.023).

Original language	English
Pages (from-to)	1207-1212
Number of pages	6
Journal	Anaesthesia
Volume	57
Issue number	12
DOIs	https://doi.org/10.1046/j.1365-2044.2002.02624_4.x
State	Published - 01 12 2002
Externally published	Yes

Keywords

Calcium-channel blockers: nicardipine
Intubation: tracheal
Sympathetic nervous system: α adrenergic antagonists, esmolol

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10.1046/j.1365-2044.2002.02624_4.x

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title = "Combined use of esmolol and nicardipine to blunt the haemodynamic changes following laryngoscopy and tracheal intubation",

abstract = "We examined the effect of different combinations of esmolol and nicardipine upon the circulatory response to tracheal intubation. One hundred patients were randomly allocated into five groups of twenty to receive pretreatments of saline or different combinations of esmolol (0.5 or 1.0 mg.kg-1) and nicardipine (15 or 30 μg.kg-1). Significant tachycardia persisted over a 5-min period after intubation in all five groups compared with baseline levels (p < 0.05). Patients receiving esmolol 1.0 mg.kg-1 and nicardipine 30 μg.kg-1 showed no significant change in systolic blood pressure after tracheal intubation compared with baseline and significant lower peak systolic blood pressure than those receiving saline (p = 0.023).",

keywords = "Calcium-channel blockers: nicardipine, Intubation: tracheal, Sympathetic nervous system: α adrenergic antagonists, esmolol",

author = "Tan, {P. H.} and Yang, {L. C.} and Shih, {H. C.} and Lin, {C. R.} and Lan, {K. C.} and Chen, {C. S.}",

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T1 - Combined use of esmolol and nicardipine to blunt the haemodynamic changes following laryngoscopy and tracheal intubation

AU - Tan, P. H.

AU - Yang, L. C.

AU - Shih, H. C.

AU - Lin, C. R.

AU - Lan, K. C.

AU - Chen, C. S.

PY - 2002/12/1

Y1 - 2002/12/1

N2 - We examined the effect of different combinations of esmolol and nicardipine upon the circulatory response to tracheal intubation. One hundred patients were randomly allocated into five groups of twenty to receive pretreatments of saline or different combinations of esmolol (0.5 or 1.0 mg.kg-1) and nicardipine (15 or 30 μg.kg-1). Significant tachycardia persisted over a 5-min period after intubation in all five groups compared with baseline levels (p < 0.05). Patients receiving esmolol 1.0 mg.kg-1 and nicardipine 30 μg.kg-1 showed no significant change in systolic blood pressure after tracheal intubation compared with baseline and significant lower peak systolic blood pressure than those receiving saline (p = 0.023).

AB - We examined the effect of different combinations of esmolol and nicardipine upon the circulatory response to tracheal intubation. One hundred patients were randomly allocated into five groups of twenty to receive pretreatments of saline or different combinations of esmolol (0.5 or 1.0 mg.kg-1) and nicardipine (15 or 30 μg.kg-1). Significant tachycardia persisted over a 5-min period after intubation in all five groups compared with baseline levels (p < 0.05). Patients receiving esmolol 1.0 mg.kg-1 and nicardipine 30 μg.kg-1 showed no significant change in systolic blood pressure after tracheal intubation compared with baseline and significant lower peak systolic blood pressure than those receiving saline (p = 0.023).

KW - Calcium-channel blockers: nicardipine

KW - Intubation: tracheal

KW - Sympathetic nervous system: α adrenergic antagonists, esmolol

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AN - SCOPUS:0036897412

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JO - Anaesthesia

JF - Anaesthesia

IS - 12

ER -

Combined use of esmolol and nicardipine to blunt the haemodynamic changes following laryngoscopy and tracheal intubation

Abstract

Keywords

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