Comorbid migraine is associated with a negative impact on quality of life in patients with major depression

C. I. Hung, C. Y. Liu, J. L. Fuh, Y. Y. Juang, S. J. Wang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

36 Scopus citations

Abstract

This study investigated the impact of migraine on health-related quality of life (HRQoL) among patients with major depressive disorder (MDD). We prospectively enrolled 151 consecutive psychiatric out-patients meeting DSM-IV criteria for MDD. Migraine and other headache types were diagnosed based on the International Classification of Headache Disorders, 2nd edition (2004). The Short Form-36 (SF-36) was administered as a generic instrument of HRQoL. Among 151 patients with MDD, migraine (N = 73, 48.3%) was very common. Comorbidity of migraine predicted a significantly negative impact on all physical subscales and vitality but not on the other mental subscales of the SF-36 after controlling for depression, age and gender. The presence of migraine should be considered as an important physical symptom in clinic-based MDD samples. Simultaneous management of depression and severe headaches, especially migraine, might improve HRQoL in patients with MDD.

Original languageEnglish
Pages (from-to)26-32
Number of pages7
JournalCephalalgia
Volume26
Issue number1
DOIs
StatePublished - 01 2006

Keywords

  • Depression
  • Headache
  • Migraine
  • Quality of life

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