Comparison of Clinical Manifestations and Pathology between Kimura Disease and IgG4-Related Disease: A Report of Two Cases and Literature Review

Sing Ya Chang; Chih Chun Lee; Ming Ling Chang; Wen Chieh Teng; Chao Yang Hsiao; Han Hua Yu; Meng Ju Hsieh; Tien Ming Chan

doi:10.3390/jcm11236887

Comparison of Clinical Manifestations and Pathology between Kimura Disease and IgG4-Related Disease: A Report of Two Cases and Literature Review

Sing Ya Chang, Chih Chun Lee, Ming Ling Chang, Wen Chieh Teng, Chao Yang Hsiao, Han Hua Yu, Meng Ju Hsieh, Tien Ming Chan^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

Abstract

Kimura disease (KD) is a rare, chronic proliferative condition presenting as a subcutaneous mass predominantly located in the head and neck region; it is characterized by eosinophilia and elevated serum IgE levels. IgG4-related disease (IgG4RD) is a fibroinflammatory condition characterized by swelling in single or multiple organs and the infiltration of IgG4 plasma cells. Herein, we presented two cases. Case 1 is a 38-year-old man with a painless mass in his right postauricular region, and Case 2 is a 36-year-old man with painless lymphadenopathy in his bilateral postauricular region. After surgical excision, they showed good recovery with no relapse. Although Cases 1 and 2 shared several overlapping pathological manifestations, there were a few differences that allowed the differentiation of KD and IgG4RD.

Original language	English
Article number	6887
Journal	Journal of Clinical Medicine
Volume	11
Issue number	23
DOIs	https://doi.org/10.3390/jcm11236887
State	Published - 12 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors.

Keywords

IgG4-related disease
Kimura disease
Taiwan
case report
overlapping features

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10.3390/jcm11236887

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title = "Comparison of Clinical Manifestations and Pathology between Kimura Disease and IgG4-Related Disease: A Report of Two Cases and Literature Review",

abstract = "Kimura disease (KD) is a rare, chronic proliferative condition presenting as a subcutaneous mass predominantly located in the head and neck region; it is characterized by eosinophilia and elevated serum IgE levels. IgG4-related disease (IgG4RD) is a fibroinflammatory condition characterized by swelling in single or multiple organs and the infiltration of IgG4 plasma cells. Herein, we presented two cases. Case 1 is a 38-year-old man with a painless mass in his right postauricular region, and Case 2 is a 36-year-old man with painless lymphadenopathy in his bilateral postauricular region. After surgical excision, they showed good recovery with no relapse. Although Cases 1 and 2 shared several overlapping pathological manifestations, there were a few differences that allowed the differentiation of KD and IgG4RD.",

keywords = "IgG4-related disease, Kimura disease, Taiwan, case report, overlapping features",

author = "Chang, {Sing Ya} and Lee, {Chih Chun} and Chang, {Ming Ling} and Teng, {Wen Chieh} and Hsiao, {Chao Yang} and Yu, {Han Hua} and Hsieh, {Meng Ju} and Chan, {Tien Ming}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = dec,

doi = "10.3390/jcm11236887",

language = "英语",

volume = "11",

journal = "Journal of Clinical Medicine",

issn = "2077-0383",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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T1 - Comparison of Clinical Manifestations and Pathology between Kimura Disease and IgG4-Related Disease

T2 - A Report of Two Cases and Literature Review

AU - Chang, Sing Ya

AU - Lee, Chih Chun

AU - Chang, Ming Ling

AU - Teng, Wen Chieh

AU - Hsiao, Chao Yang

AU - Yu, Han Hua

AU - Hsieh, Meng Ju

AU - Chan, Tien Ming

PY - 2022/12

Y1 - 2022/12

N2 - Kimura disease (KD) is a rare, chronic proliferative condition presenting as a subcutaneous mass predominantly located in the head and neck region; it is characterized by eosinophilia and elevated serum IgE levels. IgG4-related disease (IgG4RD) is a fibroinflammatory condition characterized by swelling in single or multiple organs and the infiltration of IgG4 plasma cells. Herein, we presented two cases. Case 1 is a 38-year-old man with a painless mass in his right postauricular region, and Case 2 is a 36-year-old man with painless lymphadenopathy in his bilateral postauricular region. After surgical excision, they showed good recovery with no relapse. Although Cases 1 and 2 shared several overlapping pathological manifestations, there were a few differences that allowed the differentiation of KD and IgG4RD.

AB - Kimura disease (KD) is a rare, chronic proliferative condition presenting as a subcutaneous mass predominantly located in the head and neck region; it is characterized by eosinophilia and elevated serum IgE levels. IgG4-related disease (IgG4RD) is a fibroinflammatory condition characterized by swelling in single or multiple organs and the infiltration of IgG4 plasma cells. Herein, we presented two cases. Case 1 is a 38-year-old man with a painless mass in his right postauricular region, and Case 2 is a 36-year-old man with painless lymphadenopathy in his bilateral postauricular region. After surgical excision, they showed good recovery with no relapse. Although Cases 1 and 2 shared several overlapping pathological manifestations, there were a few differences that allowed the differentiation of KD and IgG4RD.

KW - IgG4-related disease

KW - Kimura disease

KW - Taiwan

KW - case report

KW - overlapping features

UR - http://www.scopus.com/inward/record.url?scp=85143617188&partnerID=8YFLogxK

U2 - 10.3390/jcm11236887

DO - 10.3390/jcm11236887

M3 - 文章

AN - SCOPUS:85143617188

SN - 2077-0383

VL - 11

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 23

M1 - 6887

ER -

Comparison of Clinical Manifestations and Pathology between Kimura Disease and IgG4-Related Disease: A Report of Two Cases and Literature Review

Abstract

Bibliographical note

Keywords

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