Comparison of Clinical Manifestations and Pathology between Kimura Disease and IgG4-Related Disease: A Report of Two Cases and Literature Review

Sing Ya Chang; Chih Chun Lee; Ming Ling Chang; Wen Chieh Teng; Chao Yang Hsiao; Han-Hua Yu; Meng Ju Hsieh; Tien Ming Chan

doi:10.3390/jcm11236887

Comparison of Clinical Manifestations and Pathology between Kimura Disease and IgG4-Related Disease: A Report of Two Cases and Literature Review

Sing Ya Chang, Chih Chun Lee, Ming Ling Chang, Wen Chieh Teng, Chao Yang Hsiao, Han-Hua Yu, Meng Ju Hsieh, Tien Ming Chan^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Abstract

Kimura disease (KD) is a rare, chronic proliferative condition presenting as a subcutaneous mass predominantly located in the head and neck region; it is characterized by eosinophilia and elevated serum IgE levels. IgG4-related disease (IgG4RD) is a fibroinflammatory condition characterized by swelling in single or multiple organs and the infiltration of IgG4 plasma cells. Herein, we presented two cases. Case 1 is a 38-year-old man with a painless mass in his right postauricular region, and Case 2 is a 36-year-old man with painless lymphadenopathy in his bilateral postauricular region. After surgical excision, they showed good recovery with no relapse. Although Cases 1 and 2 shared several overlapping pathological manifestations, there were a few differences that allowed the differentiation of KD and IgG4RD.

Original language	English
Article number	6887
Journal	Journal of Clinical Medicine
Volume	11
Issue number	23
DOIs	https://doi.org/10.3390/jcm11236887
State	Published - 12 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors.

Keywords

IgG4-related disease
Kimura disease
Taiwan
case report
overlapping features

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title = "Comparison of Clinical Manifestations and Pathology between Kimura Disease and IgG4-Related Disease: A Report of Two Cases and Literature Review",

abstract = "Kimura disease (KD) is a rare, chronic proliferative condition presenting as a subcutaneous mass predominantly located in the head and neck region; it is characterized by eosinophilia and elevated serum IgE levels. IgG4-related disease (IgG4RD) is a fibroinflammatory condition characterized by swelling in single or multiple organs and the infiltration of IgG4 plasma cells. Herein, we presented two cases. Case 1 is a 38-year-old man with a painless mass in his right postauricular region, and Case 2 is a 36-year-old man with painless lymphadenopathy in his bilateral postauricular region. After surgical excision, they showed good recovery with no relapse. Although Cases 1 and 2 shared several overlapping pathological manifestations, there were a few differences that allowed the differentiation of KD and IgG4RD.",

keywords = "IgG4-related disease, Kimura disease, Taiwan, case report, overlapping features",

author = "Chang, \{Sing Ya\} and Lee, \{Chih Chun\} and Chang, \{Ming Ling\} and Teng, \{Wen Chieh\} and Hsiao, \{Chao Yang\} and Han-Hua Yu and Hsieh, \{Meng Ju\} and Chan, \{Tien Ming\}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = dec,

doi = "10.3390/jcm11236887",

language = "英语",

volume = "11",

journal = "Journal of Clinical Medicine",

issn = "2077-0383",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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T1 - Comparison of Clinical Manifestations and Pathology between Kimura Disease and IgG4-Related Disease

T2 - A Report of Two Cases and Literature Review

AU - Chang, Sing Ya

AU - Lee, Chih Chun

AU - Chang, Ming Ling

AU - Teng, Wen Chieh

AU - Hsiao, Chao Yang

AU - Yu, Han-Hua

AU - Hsieh, Meng Ju

AU - Chan, Tien Ming

PY - 2022/12

Y1 - 2022/12

N2 - Kimura disease (KD) is a rare, chronic proliferative condition presenting as a subcutaneous mass predominantly located in the head and neck region; it is characterized by eosinophilia and elevated serum IgE levels. IgG4-related disease (IgG4RD) is a fibroinflammatory condition characterized by swelling in single or multiple organs and the infiltration of IgG4 plasma cells. Herein, we presented two cases. Case 1 is a 38-year-old man with a painless mass in his right postauricular region, and Case 2 is a 36-year-old man with painless lymphadenopathy in his bilateral postauricular region. After surgical excision, they showed good recovery with no relapse. Although Cases 1 and 2 shared several overlapping pathological manifestations, there were a few differences that allowed the differentiation of KD and IgG4RD.

AB - Kimura disease (KD) is a rare, chronic proliferative condition presenting as a subcutaneous mass predominantly located in the head and neck region; it is characterized by eosinophilia and elevated serum IgE levels. IgG4-related disease (IgG4RD) is a fibroinflammatory condition characterized by swelling in single or multiple organs and the infiltration of IgG4 plasma cells. Herein, we presented two cases. Case 1 is a 38-year-old man with a painless mass in his right postauricular region, and Case 2 is a 36-year-old man with painless lymphadenopathy in his bilateral postauricular region. After surgical excision, they showed good recovery with no relapse. Although Cases 1 and 2 shared several overlapping pathological manifestations, there were a few differences that allowed the differentiation of KD and IgG4RD.

KW - IgG4-related disease

KW - Kimura disease

KW - Taiwan

KW - case report

KW - overlapping features

UR - https://www.scopus.com/pages/publications/85143617188

U2 - 10.3390/jcm11236887

DO - 10.3390/jcm11236887

M3 - 文章

AN - SCOPUS:85143617188

SN - 2077-0383

VL - 11

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 23

M1 - 6887

ER -

Comparison of Clinical Manifestations and Pathology between Kimura Disease and IgG4-Related Disease: A Report of Two Cases and Literature Review

Abstract

Bibliographical note

Keywords

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