Comparison of CYFRA 21-1 and tissue polypeptide specific antigen (TPS) for detecting nasopharyngeal carcinoma

Chih Jaan Tai, Feng Yuan Liu, Ji An Liang, Shih Neng Yang, Ming Hsui Tsai, Cbia Hung Kao*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

14 Scopus citations

Abstract

CYFRA 21-1 is a tumor marker that is useful for detecting squamous cell carcinoma (SCC) of the lung. Tissue polypeptide specific antigen (TPS) is a tumor marker that indicates tumor proliferative rate rather than tumor burden. Our aim in this study was to compare the clinical value of CYFRA 21-1 and TPS in the detection of nasopharyngeal carcinoma (NPC). Serum levels of CYFRA 21-1 and TPS were measured in 60 patients with untreated NPC (including 36 differentiated SCC and 24 undifferentiated carcinomas) for comparison with each other. The cut-off values of CYFRA 21-1 and TPS, determined at the 95th percentile of the 43 healthy controls, were 2.50 ng/ml and 115.2 U/l, respectively. The results revealed that the mean serum values of CYFRA 21-1 (6.20 ± 5.21 ng/ml) and TPS (153.9 ± 17.3 U/l) in all 60 NPC patients were significantly higher than that in the 43 healthy controls (CYFRA 21-1 = 1. 32 -+ 0.50 ng/ml, TPS = 85.0 ± 16 0 U/l) (p value < O.05). In addition, the detecting sensitivities of CYFRA 21-1 (60. 0%) and TPS (58. 3%) for all 60 NPC were not significantly different (p value > O. 05). In conclusion, our results suggest that both CYFRA 21-1 and TPS are potential tumor markers for the detection of NPC.

Original languageEnglish
Pages (from-to)3793-3796
Number of pages4
JournalAnticancer Research
Volume22
Issue number6 B
StatePublished - 11 2002
Externally publishedYes

Keywords

  • CYFRA 21-1
  • Nasopharygeal carcinoma
  • TPS

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