Comparison of interferon-γ response between tuberculosis and non-tubercular pneumonia

H. P. Wu*, C. C. Hua, Y. C. Liu, D. Y. Chuang

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

5 Scopus citations

Abstract

Objective and design: Macrophages aided by interferon-gamma (IFN-γ) are vital to controlling Mycobacterium tuberculosis (M. tuberculosis) infection. Although numerous studies have compared IFN-γ response between tubercular patients and healthy controls, no studies have investigated IFN-γ response in patients with pulmonary tuberculosis and non-tubercular pneumonia. The aim of this work was to examine the difference in IFN-γ response between patients with tuberculosis and non-tubercular pneumonia. Methods: IFN-γ production was detected based on the difference in supernatants between non-stimulated and stimulated peripheral blood mononuclear cells by phytohemagglutinin in 83 tubercular patients and 47 patients with pneumonia. Presence of a cavity on chest radiography and co-morbidities of pneumoconiosis, bronchiectasis, liver cirrhosis, renal failure on hemodialysis, diabetes mellitus (DM) and lung cancer were recorded for analysis. Results: Interferon-gamma response, DM and a cavity on chest radiography were independent factors for predicting active pulmonary tuberculosis. Interferon-gamma response was decreased in patients with pulmonary tuberculosis compared with that in patients with non-tubercular pneumonia. Notably, M. tuberculosis infection was the principal factor correlated with IFN-γ response. Conclusion: The IFN-γ response was principally affected by M. tuberculosis infection and not by other co-morbidities. Further study is required to identify the mechanism of decreased IFN-γ production.

Original languageEnglish
Pages (from-to)11-16
Number of pages6
JournalInflammation Research
Volume56
Issue number1
DOIs
StatePublished - 01 2007

Keywords

  • Cavity
  • Diabetes mellitus
  • Interferon-gamma
  • Pneumoconiosis
  • Tuberculosis

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