Complementary Utility of Dopamine Transporter and Tau PET Imaging in the Diagnosis of Progressive Supranuclear Palsy: A Case Report

Chenhao Jia; Meiqi Wu; Tzu Chen Yen; Yanfeng Li; Ruixue Cui

doi:10.1097/RLU.0000000000003974

Complementary Utility of Dopamine Transporter and Tau PET Imaging in the Diagnosis of Progressive Supranuclear Palsy: A Case Report

Chenhao Jia, Meiqi Wu, Tzu Chen Yen, Yanfeng Li, Ruixue Cui^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

A 50-year-old woman developed gait disturbances, tendency to fall backwards, bradykinesia, and memory loss over the previous 6 months. Brain 18F-FDG PET/CT was unable to distinguish among APSs (atypical parkinsonian syndromes); PET investigations of dopamine transporter (DAT) function (11C-CFT) and tau pathology (18F-APN-1607) were performed. 11C-CFT PET revealed severe loss of striatal DAT function, whereas significant tau accumulation was observed in the brainstem, basal ganglia, and globus pallidus on 18F-APN-1607 PET. Such finding suggested diagnosis of PSP (progressive supranuclear palsy). This case highlights the value of DAT and tau PET imaging in diagnosis of PSP and differential diagnosis ofAPSs.

Original language	English
Pages (from-to)	336-338
Number of pages	3
Journal	Clinical Nuclear Medicine
Volume	47
Issue number	4
DOIs	https://doi.org/10.1097/RLU.0000000000003974
State	Published - 01 04 2022
Externally published	Yes

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Keywords

atypical parkinsonian syndromes
dopamine transporter function
positron emission tomography
progressive supranuclear palsy
tau imaging

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title = "Complementary Utility of Dopamine Transporter and Tau PET Imaging in the Diagnosis of Progressive Supranuclear Palsy: A Case Report",

abstract = "A 50-year-old woman developed gait disturbances, tendency to fall backwards, bradykinesia, and memory loss over the previous 6 months. Brain 18F-FDG PET/CT was unable to distinguish among APSs (atypical parkinsonian syndromes); PET investigations of dopamine transporter (DAT) function (11C-CFT) and tau pathology (18F-APN-1607) were performed. 11C-CFT PET revealed severe loss of striatal DAT function, whereas significant tau accumulation was observed in the brainstem, basal ganglia, and globus pallidus on 18F-APN-1607 PET. Such finding suggested diagnosis of PSP (progressive supranuclear palsy). This case highlights the value of DAT and tau PET imaging in diagnosis of PSP and differential diagnosis ofAPSs.",

keywords = "atypical parkinsonian syndromes, dopamine transporter function, positron emission tomography, progressive supranuclear palsy, tau imaging",

author = "Chenhao Jia and Meiqi Wu and Yen, {Tzu Chen} and Yanfeng Li and Ruixue Cui",

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T2 - A Case Report

AU - Jia, Chenhao

AU - Wu, Meiqi

AU - Yen, Tzu Chen

AU - Li, Yanfeng

AU - Cui, Ruixue

PY - 2022/4/1

Y1 - 2022/4/1

N2 - A 50-year-old woman developed gait disturbances, tendency to fall backwards, bradykinesia, and memory loss over the previous 6 months. Brain 18F-FDG PET/CT was unable to distinguish among APSs (atypical parkinsonian syndromes); PET investigations of dopamine transporter (DAT) function (11C-CFT) and tau pathology (18F-APN-1607) were performed. 11C-CFT PET revealed severe loss of striatal DAT function, whereas significant tau accumulation was observed in the brainstem, basal ganglia, and globus pallidus on 18F-APN-1607 PET. Such finding suggested diagnosis of PSP (progressive supranuclear palsy). This case highlights the value of DAT and tau PET imaging in diagnosis of PSP and differential diagnosis ofAPSs.

AB - A 50-year-old woman developed gait disturbances, tendency to fall backwards, bradykinesia, and memory loss over the previous 6 months. Brain 18F-FDG PET/CT was unable to distinguish among APSs (atypical parkinsonian syndromes); PET investigations of dopamine transporter (DAT) function (11C-CFT) and tau pathology (18F-APN-1607) were performed. 11C-CFT PET revealed severe loss of striatal DAT function, whereas significant tau accumulation was observed in the brainstem, basal ganglia, and globus pallidus on 18F-APN-1607 PET. Such finding suggested diagnosis of PSP (progressive supranuclear palsy). This case highlights the value of DAT and tau PET imaging in diagnosis of PSP and differential diagnosis ofAPSs.

KW - atypical parkinsonian syndromes

KW - dopamine transporter function

KW - positron emission tomography

KW - progressive supranuclear palsy

KW - tau imaging

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Complementary Utility of Dopamine Transporter and Tau PET Imaging in the Diagnosis of Progressive Supranuclear Palsy: A Case Report

Abstract

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Keywords

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