TY - JOUR
T1 - Complete mtDNA genomes of Filipino ethnolinguistic groups
T2 - A melting pot of recent and ancient lineages in the Asia-Pacific region
AU - Delfin, Frederick
AU - Min-Shan Ko, Albert
AU - Li, Mingkun
AU - Gunnarsdóttir, Ellen D.
AU - Tabbada, Kristina A.
AU - Salvador, Jazelyn M.
AU - Calacal, Gayvelline C.
AU - Sagum, Minerva S.
AU - Datar, Francisco A.
AU - Padilla, Sabino G.
AU - De Ungria, Maria Corazon A.
AU - Stoneking, Mark
PY - 2014/2
Y1 - 2014/2
N2 - The Philippines is a strategic point in the Asia-Pacific region for the study of human diversity, history and origins, as it is a cross-road for human migrations and consequently exhibits enormous ethnolinguistic diversity. Following on a previous in-depth study of Y-chromosome variation, here we provide new insights into the maternal genetic history of Filipino ethnolinguistic groups by surveying complete mitochondrial DNA (mtDNA) genomes from a total of 14 groups (11 groups in this study and 3 groups previously published) including previously published mtDNA hypervariable segment (HVS) data from Filipino regional center groups. Comparison of HVS data indicate genetic differences between ethnolinguistic and regional center groups. The complete mtDNA genomes of 14 ethnolinguistic groups reveal genetic aspects consistent with the Y-chromosome, namely: diversity and heterogeneity of groups, no support for a simple dichotomy between Negrito and non-Negrito groups, and different genetic affinities with Asia-Pacific groups that are both ancient and recent. Although some mtDNA haplogroups can be associated with the Austronesian expansion, there are others that associate with South Asia, Near Oceania and Australia that are consistent with a southern migration route for ethnolinguistic group ancestors into the Asia-Pacific, with a timeline that overlaps with the initial colonization of the Asia-Pacific region, the initial colonization of the Philippines and a possible separate post-colonization migration into the Philippine archipelago.
AB - The Philippines is a strategic point in the Asia-Pacific region for the study of human diversity, history and origins, as it is a cross-road for human migrations and consequently exhibits enormous ethnolinguistic diversity. Following on a previous in-depth study of Y-chromosome variation, here we provide new insights into the maternal genetic history of Filipino ethnolinguistic groups by surveying complete mitochondrial DNA (mtDNA) genomes from a total of 14 groups (11 groups in this study and 3 groups previously published) including previously published mtDNA hypervariable segment (HVS) data from Filipino regional center groups. Comparison of HVS data indicate genetic differences between ethnolinguistic and regional center groups. The complete mtDNA genomes of 14 ethnolinguistic groups reveal genetic aspects consistent with the Y-chromosome, namely: diversity and heterogeneity of groups, no support for a simple dichotomy between Negrito and non-Negrito groups, and different genetic affinities with Asia-Pacific groups that are both ancient and recent. Although some mtDNA haplogroups can be associated with the Austronesian expansion, there are others that associate with South Asia, Near Oceania and Australia that are consistent with a southern migration route for ethnolinguistic group ancestors into the Asia-Pacific, with a timeline that overlaps with the initial colonization of the Asia-Pacific region, the initial colonization of the Philippines and a possible separate post-colonization migration into the Philippine archipelago.
KW - Filipino ethnolinguistic
KW - complete mitochondrial genome
KW - genetic affinity
UR - http://www.scopus.com/inward/record.url?scp=84892831194&partnerID=8YFLogxK
U2 - 10.1038/ejhg.2013.122
DO - 10.1038/ejhg.2013.122
M3 - 文章
C2 - 23756438
AN - SCOPUS:84892831194
SN - 1018-4813
VL - 22
SP - 228
EP - 237
JO - European Journal of Human Genetics
JF - European Journal of Human Genetics
IS - 2
ER -