Abstract
Objective: Recurrent cervical cancer is hard to treat when occurring in a previous radiated area and unresectable or distant metastasis. We present three such cases who achieved complete remission (CR) after chemoradiotherapy and pembrolizumab. Case Report: Case 1 was diagnosed with cervical adenocarcinoma, stage IVB. She obtained CR after concurrent chemoradiotherapy (CCRT) and post-CCRT adjuvant chemotherapy and bevacizumab. Recurrence at previous irradiated sacral bone was controlled with pembrolizumab and CCRT using proton therapy (PT). Case 2 was diagnosed with stage IVB squamous cell carcinoma. First recurrence occurred at inguinal lymph node (LN). Secondary recurrence occurred at paraaortic LN ten years later. PT with chemotherapy and pembrolizumab achieved CR. Case 3 had a small cell carcinoma (stage IVB) with bone metastasis. She had CR to CCRT with etoposide-cisplatin. Liver metastasis was salvaged with CCRT and pembrolizumab. Conclusion: CCRT with pembrolizumab is potentially curative for recurrent cervical cancer conventionally amenable for palliation.
| Original language | English |
|---|---|
| Pages (from-to) | 938-941 |
| Number of pages | 4 |
| Journal | Taiwanese Journal of Obstetrics and Gynecology |
| Volume | 60 |
| Issue number | 5 |
| DOIs | |
| State | Published - 09 2021 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2021
Keywords
- Chemoradiation therapy
- Immune check point inhibitor
- Pembrolizumab
- Recurrent/advanced cervical cancer
