Complex genomic variants contribute toward the genetic architecture of autism spectrum disorder

Chia Hsiang Chen; Hsiao Mei Liao; Hsin I. Chen; Jye Siung Fang; Yan Jang Chen; Kuei Fang Lee; Susan Shur Fen Gau

doi:10.1097/YPG.0000000000000120

Complex genomic variants contribute toward the genetic architecture of autism spectrum disorder

Chia Hsiang Chen, Hsiao Mei Liao, Hsin I. Chen, Jye Siung Fang, Yan Jang Chen, Kuei Fang Lee, Susan Shur Fen Gau

Department of Biomedical Sciences (Master's Program in Clinical Trials Assessment)

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Abstract

Genetic factor plays a critical role in the etiology of autism spectrum disorder (ASD). Both common variants with a small effect and rare mutations with a large effect contribute toward the genetic basis of ASD, showing the high genetic heterogeneity of ASD. Genomic rearrangements account for around 10-15% of its genetic landscape. However, they are highly individualized and each of them has a very rare frequency.

Original language	English
Pages (from-to)	95-96
Number of pages	2
Journal	Psychiatric Genetics
Volume	26
Issue number	2
DOIs	https://doi.org/10.1097/YPG.0000000000000120
State	Published - 01 04 2016

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10.1097/YPG.0000000000000120

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AU - Lee, Kuei Fang

AU - Gau, Susan Shur Fen

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Complex genomic variants contribute toward the genetic architecture of autism spectrum disorder

Abstract

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