Complexes formation between insulin receptor and extracellular signal-regulated kinases ERKs

Yea Lih Lin; Clément Mettling; Chen Kung Chou

doi:10.1006/mcbr.2001.0286

Complexes formation between insulin receptor and extracellular signal-regulated kinases ERKs

Yea Lih Lin^*, Clément Mettling, Chen Kung Chou

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

1 Scopus citations

Abstract

A property of signal transduction pathways that might explain their efficiency and specificity is the formation of signaling complexes. The recent demonstration that adaptor proteins can interact with many components of the extracellular signal-regulated kinases (ERKs) signaling cascade leads us to investigate whether such complexes may include the transmembrane receptor. The present work shows that in human hepatoma Hep3B cells, insulin receptor (IR) can be coimmunoprecipitated with other components of the ERKs cascade: insulin receptor substrate (IRS), Raf-1, and ERKs. Furthermore, these complexes formed near the cytoplasmic membrane even prior to insulin stimulation.

Original language	English
Pages (from-to)	234-238
Number of pages	5
Journal	Molecular Cell Biology Research Communications
Volume	4
Issue number	4
DOIs	https://doi.org/10.1006/mcbr.2001.0286
State	Published - 2000
Externally published	Yes

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title = "Complexes formation between insulin receptor and extracellular signal-regulated kinases ERKs",

abstract = "A property of signal transduction pathways that might explain their efficiency and specificity is the formation of signaling complexes. The recent demonstration that adaptor proteins can interact with many components of the extracellular signal-regulated kinases (ERKs) signaling cascade leads us to investigate whether such complexes may include the transmembrane receptor. The present work shows that in human hepatoma Hep3B cells, insulin receptor (IR) can be coimmunoprecipitated with other components of the ERKs cascade: insulin receptor substrate (IRS), Raf-1, and ERKs. Furthermore, these complexes formed near the cytoplasmic membrane even prior to insulin stimulation.",

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AU - Mettling, Clément

AU - Chou, Chen Kung

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AB - A property of signal transduction pathways that might explain their efficiency and specificity is the formation of signaling complexes. The recent demonstration that adaptor proteins can interact with many components of the extracellular signal-regulated kinases (ERKs) signaling cascade leads us to investigate whether such complexes may include the transmembrane receptor. The present work shows that in human hepatoma Hep3B cells, insulin receptor (IR) can be coimmunoprecipitated with other components of the ERKs cascade: insulin receptor substrate (IRS), Raf-1, and ERKs. Furthermore, these complexes formed near the cytoplasmic membrane even prior to insulin stimulation.

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U2 - 10.1006/mcbr.2001.0286

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Complexes formation between insulin receptor and extracellular signal-regulated kinases ERKs

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