Components from the leaves and twigs of mangrove lumnitzera racemosa with anti-angiogenic and anti-inflammatory effects

One new neolignan, racelactone A (1), together with seven known compounds (2−8) were isolated from the methanolic extract of the leaves and twigs of Lumnitzera racemosa. The structure of racelactone A (1) was determined on the basis of the mass and NMR spectroscopic data interpretation. With respect to bioactivity, compound 1 displayed an anti-angiogenic effect by suppressing tube formation. Furthermore, compounds 1, 4, and 5 showed significant anti-inflammatory effects with IC₅₀ values of 4.95 ± 0.89, 1.95 ± 0.40, and 2.57 ± 0.23 µM, respectively. The plausible biosynthesis pathway of racelactone A (1) was proposed.