Composite bone graft of CaO–MgO–SiO2 glass–ceramics and CaSO4 ceramics for boosting bone formation rate

Guan Yi Hung; Chi Yun Wang; Hui Yi Hsiao; Chi Shun Tu; Haidee Mana-Ay; Ching Ting Chen; Po Liang Lai; Kuei Chih Feng; Pin Yi Chen

doi:10.1039/d4tb00262h

Composite bone graft of CaO–MgO–SiO2 glass–ceramics and CaSO4 ceramics for boosting bone formation rate

Guan Yi Hung, Chi Yun Wang, Hui Yi Hsiao, Chi Shun Tu, Haidee Mana-Ay, Ching Ting Chen, Po Liang Lai^*, Kuei Chih Feng^*, Pin Yi Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

Abstract

This study develops a composite bone graft of CaO-MgO-SiO₂ glass-ceramic and CaSO₄ [abbreviated as (CMS)_3−x(CS)_x] via the sponge replication technique with weight fractions of x = 0, 1, 1.5, 2, and 3. The (CMS)_1.5(CS)_1.5 composite displays a superior degradability and, a suitable compressive strength of ∼3 MPa, and excellent cell proliferation and differentiation. The in vivo rat femur test in the hybrid-pore (CMS)_1.5(CS)_1.5 composite granules achieves a higher rate of bone formation, which is ∼2.7 times better than that of the commercial HAP/β-TCP at 12 weeks. Improved expressions of osteocyte and mature osteocyte marker genes, namely (Spp1, Dmp1, and Fgf23), were observed in the (CMS)_1.5(CS)_1.5 group, indicating a faster differentiation into mature bone tissue. The ions release of (CMS)_1.5(CS)_1.5 through the ERK1/2 signaling pathway promotes osteogenic differentiation. The high bone generation rate can be attributed to faster active ions release and modified surface topography. This work highlights an excellent bone graft candidate for clinical applications in orthopedic surgery.

Original language	English
Pages (from-to)	6394-6409
Number of pages	16
Journal	Journal of Materials Chemistry B
Volume	12
Issue number	26
DOIs	https://doi.org/10.1039/d4tb00262h
State	Published - 03 07 2024

Bibliographical note

Publisher Copyright:
© 2024 The Royal Society of Chemistry.

Keywords

Ceramics/chemistry
Animals
Osteogenesis/drug effects
Rats
Cell Differentiation/drug effects
Calcium Compounds/chemistry
Rats, Sprague-Dawley
Cell Proliferation/drug effects
Oxides/chemistry
Silicon Dioxide/chemistry
Male
Bone Substitutes/chemistry
Bone Transplantation/methods
Magnesium Oxide/chemistry
Surface Properties
Femur

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10.1039/d4tb00262h

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@article{8a701855f7a84665909da382bf09ef0b,

title = "Composite bone graft of CaO–MgO–SiO2 glass–ceramics and CaSO4 ceramics for boosting bone formation rate",

abstract = "This study develops a composite bone graft of CaO-MgO-SiO2 glass-ceramic and CaSO4 [abbreviated as (CMS)3−x(CS)x] via the sponge replication technique with weight fractions of x = 0, 1, 1.5, 2, and 3. The (CMS)1.5(CS)1.5 composite displays a superior degradability and, a suitable compressive strength of ∼3 MPa, and excellent cell proliferation and differentiation. The in vivo rat femur test in the hybrid-pore (CMS)1.5(CS)1.5 composite granules achieves a higher rate of bone formation, which is ∼2.7 times better than that of the commercial HAP/β-TCP at 12 weeks. Improved expressions of osteocyte and mature osteocyte marker genes, namely (Spp1, Dmp1, and Fgf23), were observed in the (CMS)1.5(CS)1.5 group, indicating a faster differentiation into mature bone tissue. The ions release of (CMS)1.5(CS)1.5 through the ERK1/2 signaling pathway promotes osteogenic differentiation. The high bone generation rate can be attributed to faster active ions release and modified surface topography. This work highlights an excellent bone graft candidate for clinical applications in orthopedic surgery.",

keywords = "Ceramics/chemistry, Animals, Osteogenesis/drug effects, Rats, Cell Differentiation/drug effects, Calcium Compounds/chemistry, Rats, Sprague-Dawley, Cell Proliferation/drug effects, Oxides/chemistry, Silicon Dioxide/chemistry, Male, Bone Substitutes/chemistry, Bone Transplantation/methods, Magnesium Oxide/chemistry, Surface Properties, Femur",

author = "Hung, {Guan Yi} and Wang, {Chi Yun} and Hsiao, {Hui Yi} and Tu, {Chi Shun} and Haidee Mana-Ay and Chen, {Ching Ting} and Lai, {Po Liang} and Feng, {Kuei Chih} and Chen, {Pin Yi}",

note = "Publisher Copyright: {\textcopyright} 2024 The Royal Society of Chemistry.",

year = "2024",

month = jul,

day = "3",

doi = "10.1039/d4tb00262h",

language = "英语",

volume = "12",

pages = "6394--6409",

journal = "Journal of Materials Chemistry B",

issn = "2050-7518",

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TY - JOUR

T1 - Composite bone graft of CaO–MgO–SiO2 glass–ceramics and CaSO4 ceramics for boosting bone formation rate

AU - Hung, Guan Yi

AU - Wang, Chi Yun

AU - Hsiao, Hui Yi

AU - Tu, Chi Shun

AU - Mana-Ay, Haidee

AU - Chen, Ching Ting

AU - Lai, Po Liang

AU - Feng, Kuei Chih

AU - Chen, Pin Yi

PY - 2024/7/3

Y1 - 2024/7/3

N2 - This study develops a composite bone graft of CaO-MgO-SiO2 glass-ceramic and CaSO4 [abbreviated as (CMS)3−x(CS)x] via the sponge replication technique with weight fractions of x = 0, 1, 1.5, 2, and 3. The (CMS)1.5(CS)1.5 composite displays a superior degradability and, a suitable compressive strength of ∼3 MPa, and excellent cell proliferation and differentiation. The in vivo rat femur test in the hybrid-pore (CMS)1.5(CS)1.5 composite granules achieves a higher rate of bone formation, which is ∼2.7 times better than that of the commercial HAP/β-TCP at 12 weeks. Improved expressions of osteocyte and mature osteocyte marker genes, namely (Spp1, Dmp1, and Fgf23), were observed in the (CMS)1.5(CS)1.5 group, indicating a faster differentiation into mature bone tissue. The ions release of (CMS)1.5(CS)1.5 through the ERK1/2 signaling pathway promotes osteogenic differentiation. The high bone generation rate can be attributed to faster active ions release and modified surface topography. This work highlights an excellent bone graft candidate for clinical applications in orthopedic surgery.

AB - This study develops a composite bone graft of CaO-MgO-SiO2 glass-ceramic and CaSO4 [abbreviated as (CMS)3−x(CS)x] via the sponge replication technique with weight fractions of x = 0, 1, 1.5, 2, and 3. The (CMS)1.5(CS)1.5 composite displays a superior degradability and, a suitable compressive strength of ∼3 MPa, and excellent cell proliferation and differentiation. The in vivo rat femur test in the hybrid-pore (CMS)1.5(CS)1.5 composite granules achieves a higher rate of bone formation, which is ∼2.7 times better than that of the commercial HAP/β-TCP at 12 weeks. Improved expressions of osteocyte and mature osteocyte marker genes, namely (Spp1, Dmp1, and Fgf23), were observed in the (CMS)1.5(CS)1.5 group, indicating a faster differentiation into mature bone tissue. The ions release of (CMS)1.5(CS)1.5 through the ERK1/2 signaling pathway promotes osteogenic differentiation. The high bone generation rate can be attributed to faster active ions release and modified surface topography. This work highlights an excellent bone graft candidate for clinical applications in orthopedic surgery.

KW - Ceramics/chemistry

KW - Animals

KW - Osteogenesis/drug effects

KW - Rats

KW - Cell Differentiation/drug effects

KW - Calcium Compounds/chemistry

KW - Rats, Sprague-Dawley

KW - Cell Proliferation/drug effects

KW - Oxides/chemistry

KW - Silicon Dioxide/chemistry

KW - Male

KW - Bone Substitutes/chemistry

KW - Bone Transplantation/methods

KW - Magnesium Oxide/chemistry

KW - Surface Properties

KW - Femur

UR - http://www.scopus.com/inward/record.url?scp=85195808397&partnerID=8YFLogxK

U2 - 10.1039/d4tb00262h

DO - 10.1039/d4tb00262h

M3 - 文章

C2 - 38855886

SN - 2050-7518

VL - 12

SP - 6394

EP - 6409

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 26

ER -

Composite bone graft of CaO–MgO–SiO2 glass–ceramics and CaSO4 ceramics for boosting bone formation rate

Abstract

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