Composition decipherment of Ficus pumila var. awkeotsang and its potential on COVID-19 symptom amelioration and in silico prediction of SARS-CoV-2 interference

Hao Chun Hu; Szu Yin Yu; Xiao Shan Hung; Chun Han Su; Yu Liang Yang; Chien Kei Wei; Yuan Bin Cheng; Yang Chang Wu; Chia Hung Yen; Tsong Long Hwang; Shu Li Chen; István Szatmári; Attila Hunyadi; Yi Hong Tsai; Fang Rong Chang

doi:10.38212/2224-6614.3419

Composition decipherment of Ficus pumila var. awkeotsang and its potential on COVID-19 symptom amelioration and in silico prediction of SARS-CoV-2 interference

Hao Chun Hu, Szu Yin Yu, Xiao Shan Hung, Chun Han Su, Yu Liang Yang, Chien Kei Wei, Yuan Bin Cheng, Yang Chang Wu, Chia Hung Yen, Tsong Long Hwang, Shu Li Chen, István Szatmári, Attila Hunyadi, Yi Hong Tsai^*, Fang Rong Chang^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

3 Scopus citations

Abstract

The jelly from achenes of Ficus pumila var. awkeotsang (FPAA) is a famous beverage ingredient in Taiwan. In this work, ficumarin (1), a new compound was obtained from its twigs (FPAT) and elucidated with comprehensive spectroscopic data. The biosynthetic origin was proposed from the p-coumaroyl-CoA pathway. Alloxanthoxyletin, betulinic acid, and catechin were identified as the major and active constituents responsible for relieving neutrophilic inflammation by FPAT. Among them, the most potent alloxanthoxyletin was found to interact with PRO350 and GLU377 of human INOSOX. Further, Nrf2 activating capacity of the FPAT fraction and its coumarins was confirmed. With the analysis of LC-MS/MS data and feature-based molecular networking, coumarins were found as the dominant and responsible components. Notably, alloxanthoxyletin increased Nrf2 expression by up to 816.8 ± 58% due to the interacting with the VAL561, THR560 and VAL420 residues of 5FNQ protein. COVID-19 Docking Server simulation indicated that pyranocoumarins would promisingly interfere with the life cycle of SARS-CoV-2. FPAT was proven to exert.

Original language	English
Article number	9
Pages (from-to)	440-453
Number of pages	14
Journal	Journal of Food and Drug Analysis
Volume	30
Issue number	3
DOIs	https://doi.org/10.38212/2224-6614.3419
State	Published - 2022

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© 2022 Taiwan Food and Drug Administration.

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Hu, H. C., Yu, S. Y., Hung, X. S., Su, C. H., Yang, Y. L., Wei, C. K., Cheng, Y. B., Wu, Y. C., Yen, C. H., Hwang, T. L., Chen, S. L., Szatmári, I., Hunyadi, A., Tsai, Y. H., & Chang, F. R. (2022). Composition decipherment of Ficus pumila var. awkeotsang and its potential on COVID-19 symptom amelioration and in silico prediction of SARS-CoV-2 interference. Journal of Food and Drug Analysis, 30(3), 440-453. Article 9. https://doi.org/10.38212/2224-6614.3419

@article{30cd286db5e74c2eb88e08f41e89e87b,

title = "Composition decipherment of Ficus pumila var. awkeotsang and its potential on COVID-19 symptom amelioration and in silico prediction of SARS-CoV-2 interference",

abstract = "The jelly from achenes of Ficus pumila var. awkeotsang (FPAA) is a famous beverage ingredient in Taiwan. In this work, ficumarin (1), a new compound was obtained from its twigs (FPAT) and elucidated with comprehensive spectroscopic data. The biosynthetic origin was proposed from the p-coumaroyl-CoA pathway. Alloxanthoxyletin, betulinic acid, and catechin were identified as the major and active constituents responsible for relieving neutrophilic inflammation by FPAT. Among them, the most potent alloxanthoxyletin was found to interact with PRO350 and GLU377 of human INOSOX. Further, Nrf2 activating capacity of the FPAT fraction and its coumarins was confirmed. With the analysis of LC-MS/MS data and feature-based molecular networking, coumarins were found as the dominant and responsible components. Notably, alloxanthoxyletin increased Nrf2 expression by up to 816.8 ± 58% due to the interacting with the VAL561, THR560 and VAL420 residues of 5FNQ protein. COVID-19 Docking Server simulation indicated that pyranocoumarins would promisingly interfere with the life cycle of SARS-CoV-2. FPAT was proven to exert.",

author = "Hu, {Hao Chun} and Yu, {Szu Yin} and Hung, {Xiao Shan} and Su, {Chun Han} and Yang, {Yu Liang} and Wei, {Chien Kei} and Cheng, {Yuan Bin} and Wu, {Yang Chang} and Yen, {Chia Hung} and Hwang, {Tsong Long} and Chen, {Shu Li} and Istv{\'a}n Szatm{\'a}ri and Attila Hunyadi and Tsai, {Yi Hong} and Chang, {Fang Rong}",

note = "Publisher Copyright: {\textcopyright} 2022 Taiwan Food and Drug Administration.",

year = "2022",

doi = "10.38212/2224-6614.3419",

language = "英语",

volume = "30",

pages = "440--453",

journal = "Journal of Food and Drug Analysis",

issn = "1021-9498",

publisher = "National Laboratories of Foods and Drugs",

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Hu, HC, Yu, SY, Hung, XS, Su, CH, Yang, YL, Wei, CK, Cheng, YB, Wu, YC, Yen, CH, Hwang, TL, Chen, SL, Szatmári, I, Hunyadi, A, Tsai, YH & Chang, FR 2022, 'Composition decipherment of Ficus pumila var. awkeotsang and its potential on COVID-19 symptom amelioration and in silico prediction of SARS-CoV-2 interference', Journal of Food and Drug Analysis, vol. 30, no. 3, 9, pp. 440-453. https://doi.org/10.38212/2224-6614.3419

TY - JOUR

T1 - Composition decipherment of Ficus pumila var. awkeotsang and its potential on COVID-19 symptom amelioration and in silico prediction of SARS-CoV-2 interference

AU - Hu, Hao Chun

AU - Yu, Szu Yin

AU - Hung, Xiao Shan

AU - Su, Chun Han

AU - Yang, Yu Liang

AU - Wei, Chien Kei

AU - Cheng, Yuan Bin

AU - Wu, Yang Chang

AU - Yen, Chia Hung

AU - Hwang, Tsong Long

AU - Chen, Shu Li

AU - Szatmári, István

AU - Hunyadi, Attila

AU - Tsai, Yi Hong

AU - Chang, Fang Rong

PY - 2022

Y1 - 2022

N2 - The jelly from achenes of Ficus pumila var. awkeotsang (FPAA) is a famous beverage ingredient in Taiwan. In this work, ficumarin (1), a new compound was obtained from its twigs (FPAT) and elucidated with comprehensive spectroscopic data. The biosynthetic origin was proposed from the p-coumaroyl-CoA pathway. Alloxanthoxyletin, betulinic acid, and catechin were identified as the major and active constituents responsible for relieving neutrophilic inflammation by FPAT. Among them, the most potent alloxanthoxyletin was found to interact with PRO350 and GLU377 of human INOSOX. Further, Nrf2 activating capacity of the FPAT fraction and its coumarins was confirmed. With the analysis of LC-MS/MS data and feature-based molecular networking, coumarins were found as the dominant and responsible components. Notably, alloxanthoxyletin increased Nrf2 expression by up to 816.8 ± 58% due to the interacting with the VAL561, THR560 and VAL420 residues of 5FNQ protein. COVID-19 Docking Server simulation indicated that pyranocoumarins would promisingly interfere with the life cycle of SARS-CoV-2. FPAT was proven to exert.

AB - The jelly from achenes of Ficus pumila var. awkeotsang (FPAA) is a famous beverage ingredient in Taiwan. In this work, ficumarin (1), a new compound was obtained from its twigs (FPAT) and elucidated with comprehensive spectroscopic data. The biosynthetic origin was proposed from the p-coumaroyl-CoA pathway. Alloxanthoxyletin, betulinic acid, and catechin were identified as the major and active constituents responsible for relieving neutrophilic inflammation by FPAT. Among them, the most potent alloxanthoxyletin was found to interact with PRO350 and GLU377 of human INOSOX. Further, Nrf2 activating capacity of the FPAT fraction and its coumarins was confirmed. With the analysis of LC-MS/MS data and feature-based molecular networking, coumarins were found as the dominant and responsible components. Notably, alloxanthoxyletin increased Nrf2 expression by up to 816.8 ± 58% due to the interacting with the VAL561, THR560 and VAL420 residues of 5FNQ protein. COVID-19 Docking Server simulation indicated that pyranocoumarins would promisingly interfere with the life cycle of SARS-CoV-2. FPAT was proven to exert.

UR - http://www.scopus.com/inward/record.url?scp=85139475219&partnerID=8YFLogxK

U2 - 10.38212/2224-6614.3419

DO - 10.38212/2224-6614.3419

M3 - 文章

AN - SCOPUS:85139475219

SN - 1021-9498

VL - 30

SP - 440

EP - 453

JO - Journal of Food and Drug Analysis

JF - Journal of Food and Drug Analysis

IS - 3

M1 - 9

ER -

Composition decipherment of Ficus pumila var. awkeotsang and its potential on COVID-19 symptom amelioration and in silico prediction of SARS-CoV-2 interference

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