TY - JOUR
T1 - Computed tomography perfusion in living donor liver transplantation
T2 - An initial study of normal hemodynamic changes in liver grafts
AU - Zhuang, Zhi Guo
AU - Qian, Li Jun
AU - Wang, Bi Xiong
AU - Zhou, Yan
AU - Li, Qi Gen
AU - Xu, Jian Rong
AU - Cheng, Yu Fan
PY - 2009/9
Y1 - 2009/9
N2 - Hepatic hemodynamic changes in grafts after living donor liver transplantation (LDLT) are complicated. In this study, computed tomography (CT) perfusion parameter values, especially portal vein perfusion (PVP), was retrospectively analyzed in recipients both with and without small-for-size syndrome (SFSS). PVP was significantly higher in non-SFSS recipients on post-operative day (POD) 14 or 28 than in normal donors before donation (p < 0.001 and p = 0.008, respectively), but it significantly decreased between 14 and 28 days post-operatively (p = 0.007). There was a significant inverse correlation between graft-to-recipient spleen size ratio and PVP on POD 14 in non-SFSS group (r = -0.545, p = 0.002). Furthermore, PVP in the SFSS group was significantly greater than in the non-SFSS group on POD 14 (p = 0.042). In conclusion, we successfully evaluated normal hemodynamic changes in grafts without SFSS by CT perfusion examination. To our knowledge, this is the first study on hemodynamic changes of living donor liver grafts using CT technique.
AB - Hepatic hemodynamic changes in grafts after living donor liver transplantation (LDLT) are complicated. In this study, computed tomography (CT) perfusion parameter values, especially portal vein perfusion (PVP), was retrospectively analyzed in recipients both with and without small-for-size syndrome (SFSS). PVP was significantly higher in non-SFSS recipients on post-operative day (POD) 14 or 28 than in normal donors before donation (p < 0.001 and p = 0.008, respectively), but it significantly decreased between 14 and 28 days post-operatively (p = 0.007). There was a significant inverse correlation between graft-to-recipient spleen size ratio and PVP on POD 14 in non-SFSS group (r = -0.545, p = 0.002). Furthermore, PVP in the SFSS group was significantly greater than in the non-SFSS group on POD 14 (p = 0.042). In conclusion, we successfully evaluated normal hemodynamic changes in grafts without SFSS by CT perfusion examination. To our knowledge, this is the first study on hemodynamic changes of living donor liver grafts using CT technique.
KW - CT perfusion
KW - Hemodynamic changes
KW - Living donor liver transplantation
KW - Portal vein perfusion
KW - Small-for-size syndrome
UR - http://www.scopus.com/inward/record.url?scp=70350173425&partnerID=8YFLogxK
U2 - 10.1111/j.1399-0012.2009.00991.x
DO - 10.1111/j.1399-0012.2009.00991.x
M3 - 文章
C2 - 19473203
AN - SCOPUS:70350173425
SN - 0902-0063
VL - 23
SP - 692
EP - 699
JO - Clinical Transplantation
JF - Clinical Transplantation
IS - 5
ER -