Computer-aided diagnosis of Alzheimer's disease using multiple features with artificial neural network

Shih Ting Yang, Jiann Der Lee*, Chung Hsien Huang, Jiun Jie Wang, Wen Chuin Hsu, Yau Yau Wai

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

12 Scopus citations

Abstract

Alzheimer's disease (AD) is a progressively neuro-degenerative disorder. In the AD-related research, the volumetric analysis of hippocampus is the most extensive study. However, the segmentation and identification of the hippocampus are highly complicated and time-consuming. Therefore, a MRI-based classification framework is proposed to differentiate between AD's patients and normal individuals. First, volumetric features and shape features were extracted from MRI data. Afterward, Principle component analysis (PCA) was utilized to decrease the dimensions of feature space. Finally, a Back-propagation artificial neural network (ANN) classifier was trained for AD classification. With the proposed framework, the classification accuracy is reached to 88.27% by only using volumetric features and shape features. And, the result achieved up to 92.17% by using volumetric features and shape features with the PCA.

Original languageEnglish
Title of host publicationPRICAI 2010
Subtitle of host publicationTrends in Artificial Intelligence - 11th Pacific Rim International Conference on Artificial Intelligence, Proceedings
Pages699-705
Number of pages7
DOIs
StatePublished - 2010
Event11th Pacific Rim International Conference on Artificial Intelligence, PRICAI 2010 - Daegu, Korea, Republic of
Duration: 30 08 201002 09 2010

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume6230 LNAI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference11th Pacific Rim International Conference on Artificial Intelligence, PRICAI 2010
Country/TerritoryKorea, Republic of
CityDaegu
Period30/08/1002/09/10

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