Computer-Aided Diagnostic Technique in 2-Deoxy-2-[                         18                         F]fluoro-D-glucose-Positive Thyroid Nodule: Clinical Experience of 74 Non-thyroid Cancer Patients

Yi Hsuan Lin; Yuan Chun Tsai; Kun Ju Lin; Jen Der Lin; Chih Ching Wang; Szu Tah Chen

doi:10.1016/j.ultrasmedbio.2018.09.002

Computer-Aided Diagnostic Technique in 2-Deoxy-2-[ ¹⁸ F]fluoro-D-glucose-Positive Thyroid Nodule: Clinical Experience of 74 Non-thyroid Cancer Patients

Yi Hsuan Lin
, Yuan Chun Tsai
, Kun Ju Lin
, Jen Der Lin
, Chih Ching Wang
, Szu Tah Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

5 Scopus citations

Abstract

This study verified the value of a computer-aided diagnosis (CAD) technique assisting in ultrasonography (US) diagnosis of 2-deoxy-2-[ ¹⁸ F]fluoro-D-glucose ( ¹⁸ FDG)-avid thyroid incidentalomas on positron emission tomography. A total of 82 ¹⁸ FDG-avid thyroid incidentalomas from 74 non-thyroid cancer patients were retrospectively analyzed with respect to US and CAD parameters (anechoic area, hyper-echoic foci, hypo-echogenicity, heterogeneity, margin, taller-than-wide shape, eccentric area) and were compared with 38 other non- ¹⁸ FDG-avid nodules found in the same patient group. Fine-needle aspiration cytology or surgical intervention pathology was performed for diagnosis. No significant differences in nodule size or CAD parameters were found in ¹⁸ FDG-avid nodules reported as benign, indeterminate or malignant. Significantly more taller-than-wide nodules were thyroid originating than metastatic (0.30 vs. 0.16, p < 0.05). Nevertheless, combined CAD and positron emission tomography/computed tomography scores and a discrimination point of 4 resulted in a sensitivity of 75% and a specificity of 80% in prediction of incidentaloma benignity.

Original language	English
Pages (from-to)	108-121
Number of pages	14
Journal	Ultrasound in Medicine and Biology
Volume	45
Issue number	1
DOIs	https://doi.org/10.1016/j.ultrasmedbio.2018.09.002
State	Published - 01 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Ltd

Keywords

Computer-aided diagnostic technique
Incidentaloma
Positron emission tomography
Standardized uptake value
Thyroid
Ultrasound

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ultrasmedbio.2018.09.002

Cite this

Lin, Y. H., Tsai, Y. C., Lin, K. J., Der Lin, J., Wang, C. C., & Chen, S. T. (2019). Computer-Aided Diagnostic Technique in 2-Deoxy-2-[ ¹⁸ F]fluoro-D-glucose-Positive Thyroid Nodule: Clinical Experience of 74 Non-thyroid Cancer Patients. Ultrasound in Medicine and Biology, 45(1), 108-121. https://doi.org/10.1016/j.ultrasmedbio.2018.09.002

@article{e6db88b8304a462d8d07b3060f0c3692,

title = "Computer-Aided Diagnostic Technique in 2-Deoxy-2-[ 18 F]fluoro-D-glucose-Positive Thyroid Nodule: Clinical Experience of 74 Non-thyroid Cancer Patients",

abstract = " This study verified the value of a computer-aided diagnosis (CAD) technique assisting in ultrasonography (US) diagnosis of 2-deoxy-2-[ 18 F]fluoro-D-glucose ( 18 FDG)-avid thyroid incidentalomas on positron emission tomography. A total of 82 18 FDG-avid thyroid incidentalomas from 74 non-thyroid cancer patients were retrospectively analyzed with respect to US and CAD parameters (anechoic area, hyper-echoic foci, hypo-echogenicity, heterogeneity, margin, taller-than-wide shape, eccentric area) and were compared with 38 other non- 18 FDG-avid nodules found in the same patient group. Fine-needle aspiration cytology or surgical intervention pathology was performed for diagnosis. No significant differences in nodule size or CAD parameters were found in 18 FDG-avid nodules reported as benign, indeterminate or malignant. Significantly more taller-than-wide nodules were thyroid originating than metastatic (0.30 vs. 0.16, p < 0.05). Nevertheless, combined CAD and positron emission tomography/computed tomography scores and a discrimination point of 4 resulted in a sensitivity of 75\% and a specificity of 80\% in prediction of incidentaloma benignity.",

keywords = "Computer-aided diagnostic technique, Incidentaloma, Positron emission tomography, Standardized uptake value, Thyroid, Ultrasound",

author = "Lin, \{Yi Hsuan\} and Tsai, \{Yuan Chun\} and Lin, \{Kun Ju\} and \{Der Lin\}, Jen and Wang, \{Chih Ching\} and Chen, \{Szu Tah\}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2019",

month = jan,

doi = "10.1016/j.ultrasmedbio.2018.09.002",

language = "英语",

volume = "45",

pages = "108--121",

journal = "Ultrasound in Medicine and Biology",

issn = "0301-5629",

publisher = "Elsevier Inc.",

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}

Lin, YH, Tsai, YC, Lin, KJ, Der Lin, J, Wang, CC & Chen, ST 2019, 'Computer-Aided Diagnostic Technique in 2-Deoxy-2-[ ¹⁸ F]fluoro-D-glucose-Positive Thyroid Nodule: Clinical Experience of 74 Non-thyroid Cancer Patients', Ultrasound in Medicine and Biology, vol. 45, no. 1, pp. 108-121. https://doi.org/10.1016/j.ultrasmedbio.2018.09.002

Computer-Aided Diagnostic Technique in 2-Deoxy-2-[ ¹⁸ F]fluoro-D-glucose-Positive Thyroid Nodule: Clinical Experience of 74 Non-thyroid Cancer Patients. / Lin, Yi Hsuan; Tsai, Yuan Chun; Lin, Kun Ju et al.
In: Ultrasound in Medicine and Biology, Vol. 45, No. 1, 01.2019, p. 108-121.

Research output: Contribution to journal › Journal Article › peer-review

TY - JOUR

T1 - Computer-Aided Diagnostic Technique in 2-Deoxy-2-[ 18 F]fluoro-D-glucose-Positive Thyroid Nodule

T2 - Clinical Experience of 74 Non-thyroid Cancer Patients

AU - Lin, Yi Hsuan

AU - Tsai, Yuan Chun

AU - Lin, Kun Ju

AU - Der Lin, Jen

AU - Wang, Chih Ching

AU - Chen, Szu Tah

PY - 2019/1

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N2 - This study verified the value of a computer-aided diagnosis (CAD) technique assisting in ultrasonography (US) diagnosis of 2-deoxy-2-[ 18 F]fluoro-D-glucose ( 18 FDG)-avid thyroid incidentalomas on positron emission tomography. A total of 82 18 FDG-avid thyroid incidentalomas from 74 non-thyroid cancer patients were retrospectively analyzed with respect to US and CAD parameters (anechoic area, hyper-echoic foci, hypo-echogenicity, heterogeneity, margin, taller-than-wide shape, eccentric area) and were compared with 38 other non- 18 FDG-avid nodules found in the same patient group. Fine-needle aspiration cytology or surgical intervention pathology was performed for diagnosis. No significant differences in nodule size or CAD parameters were found in 18 FDG-avid nodules reported as benign, indeterminate or malignant. Significantly more taller-than-wide nodules were thyroid originating than metastatic (0.30 vs. 0.16, p < 0.05). Nevertheless, combined CAD and positron emission tomography/computed tomography scores and a discrimination point of 4 resulted in a sensitivity of 75% and a specificity of 80% in prediction of incidentaloma benignity.

AB - This study verified the value of a computer-aided diagnosis (CAD) technique assisting in ultrasonography (US) diagnosis of 2-deoxy-2-[ 18 F]fluoro-D-glucose ( 18 FDG)-avid thyroid incidentalomas on positron emission tomography. A total of 82 18 FDG-avid thyroid incidentalomas from 74 non-thyroid cancer patients were retrospectively analyzed with respect to US and CAD parameters (anechoic area, hyper-echoic foci, hypo-echogenicity, heterogeneity, margin, taller-than-wide shape, eccentric area) and were compared with 38 other non- 18 FDG-avid nodules found in the same patient group. Fine-needle aspiration cytology or surgical intervention pathology was performed for diagnosis. No significant differences in nodule size or CAD parameters were found in 18 FDG-avid nodules reported as benign, indeterminate or malignant. Significantly more taller-than-wide nodules were thyroid originating than metastatic (0.30 vs. 0.16, p < 0.05). Nevertheless, combined CAD and positron emission tomography/computed tomography scores and a discrimination point of 4 resulted in a sensitivity of 75% and a specificity of 80% in prediction of incidentaloma benignity.

KW - Computer-aided diagnostic technique

KW - Incidentaloma

KW - Positron emission tomography

KW - Standardized uptake value

KW - Thyroid

KW - Ultrasound

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U2 - 10.1016/j.ultrasmedbio.2018.09.002

DO - 10.1016/j.ultrasmedbio.2018.09.002

M3 - 文章

C2 - 30336966

AN - SCOPUS:85054731001

SN - 0301-5629

VL - 45

SP - 108

EP - 121

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

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ER -