Computerized biological brain phantom for evaluation of PET and SPECT reconstruction

D. A. Dougherty; I. T. Hsiao; W. Wang; G. R. Gindi

Computerized biological brain phantom for evaluation of PET and SPECT reconstruction

D. A. Dougherty^*
, I. T. Hsiao
, W. Wang
, G. R. Gindi

^*Corresponding author for this work

Stony Brook University

Research output: Contribution to conference › Conference Paper › peer-review

Abstract

A digital brain phantom was created from available primate autoradiographic (AR) data for use in emission computed tomography studies. The tissue was radio-labelled with a functional analogue of the PET agent [¹⁸F]-fluoro-deoxyglucose (FDG). Following sacrifice of the animal, film records from serial 20 μm thickness sections were digitized and calibrated to obtain ground truth 2D spatial distributions of relative radionuclide density. A 3D version was constructed by using a video subtraction method to align consecutive slices. In order to assess the effects of accurate modelling of activity, the AR data, containing cortical and basal ganglia structures, was used as a phantom in the context of a partial-volume correction method for obtaining accurate regional quantitation. A second phantom, less realistic in terms of activity assignment, was constructed and also tested. The results indicate that quantitation errors due to effects of nonuniform activity in the AR phantom are significant and comparable in magnitude to errors due to non-phantom effects.

Original language	English
Pages	1394-1398
Number of pages	5
State	Published - 1997
Externally published	Yes
Event	Proceedings of the 1997 IEEE Nuclear Science Symposium - Albuquerque, NM, USA Duration: 09 11 1997 → 15 11 1997

Conference

Conference	Proceedings of the 1997 IEEE Nuclear Science Symposium
City	Albuquerque, NM, USA
Period	09/11/97 → 15/11/97

Cite this

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title = "Computerized biological brain phantom for evaluation of PET and SPECT reconstruction",

abstract = "A digital brain phantom was created from available primate autoradiographic (AR) data for use in emission computed tomography studies. The tissue was radio-labelled with a functional analogue of the PET agent [18F]-fluoro-deoxyglucose (FDG). Following sacrifice of the animal, film records from serial 20 μm thickness sections were digitized and calibrated to obtain ground truth 2D spatial distributions of relative radionuclide density. A 3D version was constructed by using a video subtraction method to align consecutive slices. In order to assess the effects of accurate modelling of activity, the AR data, containing cortical and basal ganglia structures, was used as a phantom in the context of a partial-volume correction method for obtaining accurate regional quantitation. A second phantom, less realistic in terms of activity assignment, was constructed and also tested. The results indicate that quantitation errors due to effects of nonuniform activity in the AR phantom are significant and comparable in magnitude to errors due to non-phantom effects.",

author = "Dougherty, \{D. A.\} and Hsiao, \{I. T.\} and W. Wang and Gindi, \{G. R.\}",

year = "1997",

language = "英语",

pages = "1394--1398",

note = "Proceedings of the 1997 IEEE Nuclear Science Symposium ; Conference date: 09-11-1997 Through 15-11-1997",

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TY - CONF

T1 - Computerized biological brain phantom for evaluation of PET and SPECT reconstruction

AU - Dougherty, D. A.

AU - Hsiao, I. T.

AU - Wang, W.

AU - Gindi, G. R.

PY - 1997

Y1 - 1997

N2 - A digital brain phantom was created from available primate autoradiographic (AR) data for use in emission computed tomography studies. The tissue was radio-labelled with a functional analogue of the PET agent [18F]-fluoro-deoxyglucose (FDG). Following sacrifice of the animal, film records from serial 20 μm thickness sections were digitized and calibrated to obtain ground truth 2D spatial distributions of relative radionuclide density. A 3D version was constructed by using a video subtraction method to align consecutive slices. In order to assess the effects of accurate modelling of activity, the AR data, containing cortical and basal ganglia structures, was used as a phantom in the context of a partial-volume correction method for obtaining accurate regional quantitation. A second phantom, less realistic in terms of activity assignment, was constructed and also tested. The results indicate that quantitation errors due to effects of nonuniform activity in the AR phantom are significant and comparable in magnitude to errors due to non-phantom effects.

AB - A digital brain phantom was created from available primate autoradiographic (AR) data for use in emission computed tomography studies. The tissue was radio-labelled with a functional analogue of the PET agent [18F]-fluoro-deoxyglucose (FDG). Following sacrifice of the animal, film records from serial 20 μm thickness sections were digitized and calibrated to obtain ground truth 2D spatial distributions of relative radionuclide density. A 3D version was constructed by using a video subtraction method to align consecutive slices. In order to assess the effects of accurate modelling of activity, the AR data, containing cortical and basal ganglia structures, was used as a phantom in the context of a partial-volume correction method for obtaining accurate regional quantitation. A second phantom, less realistic in terms of activity assignment, was constructed and also tested. The results indicate that quantitation errors due to effects of nonuniform activity in the AR phantom are significant and comparable in magnitude to errors due to non-phantom effects.

UR - https://www.scopus.com/pages/publications/0031345962

M3 - 论文

AN - SCOPUS:0031345962

SP - 1394

EP - 1398

T2 - Proceedings of the 1997 IEEE Nuclear Science Symposium

Y2 - 9 November 1997 through 15 November 1997

ER -

Computerized biological brain phantom for evaluation of PET and SPECT reconstruction

Abstract

Conference

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