Connatal tuberculosis in a very premature infant

Mei Ling Chang, Shiann Tarng Jou, Chao Ran Wang, Ming Tsung Chung, Shen Hao Lai, Kin Sun Wong, Yhu Chering Huang, Yi Hung Chou*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

12 Scopus citations


Connatal tuberculosis is increasing in incidence and the mortality and morbidity of this disease remains high. We report a 27-week-old, 896 g female premature infant who had mild respiratory distress syndrome after birth. She developed signs of infection, progressive pneumonia and atelectasis which did not respond to mechanical ventilation and antibiotics. At 41 days of age, Mycobacterium tuberculosis was isolated from the non-bronchoscopic bronchoalveolar lavage. The isolate was sensitive to isoniazid, rifampin, streptomycin, and pyrazinamide . Miliary tuberculosis was subsequently diagnosed in her mother on a chest X-ray film and sputum cultures. The infant was treated successfully with anti-tuberculosis drugs. She had normal growth and development at the chronological age of 20 months old. Conclusion:Connatal tuberculosis should be considered in premature infants with symptoms of sepsis refractory to antibiotics. Most premature infants with connatal tuberculosis have lung involvement, and non-bronchoscopic bronchoalveolar lavage can be a useful procedure to establish the diagnosis.

Original languageEnglish
Pages (from-to)244-247
Number of pages4
JournalEuropean Journal of Pediatrics
Issue number4
StatePublished - 04 2005
Externally publishedYes


  • Congenital tuberculosis
  • Connatal tuberculosis
  • Non-bronchoscopic bronchoalveolar lavage
  • Premature


Dive into the research topics of 'Connatal tuberculosis in a very premature infant'. Together they form a unique fingerprint.

Cite this