TY - JOUR
T1 - Constituents and cytotoxic principles of Nothapodytes foetida
AU - Wu, Tian Shung
AU - Leu, Yann Lii
AU - Hsu, Hua Chun
AU - Ou, Li Fei
AU - Chen, Chien Chih
AU - Chen, Chieh Fu
AU - Ou, Jun Chih
AU - Wu, Yang Chang
PY - 1995/5
Y1 - 1995/5
N2 - A new naturally occurring alkaloid, acetylcamptothecin, together with 17 known compounds, (+)-1-hydroxypinoresinol, ω-hydroxypropioguaiacone, p-hydroxybenzaldehyde, scopoletin, uracil, thymine, sitosterol, sitosteryl-β-d-glucoside, 3β-hydroxy-stigmast-5-en-7-one, stigmast-5-en-3β,7α-diol, 6β-hydroxystigmast-4-en-3-one, sitost-4-en-3-one, linoleic acid, trigonelline, camptothecin, 9-O-methoxycamptothecin and pumiloside were isolated and characterized from the stem of Nothapodytes foetida. Among them, scopoletin, camptothecin, 9-O-methoxycamptothecin and O-acetylcamptothecin showed significant cytotoxic activity.
AB - A new naturally occurring alkaloid, acetylcamptothecin, together with 17 known compounds, (+)-1-hydroxypinoresinol, ω-hydroxypropioguaiacone, p-hydroxybenzaldehyde, scopoletin, uracil, thymine, sitosterol, sitosteryl-β-d-glucoside, 3β-hydroxy-stigmast-5-en-7-one, stigmast-5-en-3β,7α-diol, 6β-hydroxystigmast-4-en-3-one, sitost-4-en-3-one, linoleic acid, trigonelline, camptothecin, 9-O-methoxycamptothecin and pumiloside were isolated and characterized from the stem of Nothapodytes foetida. Among them, scopoletin, camptothecin, 9-O-methoxycamptothecin and O-acetylcamptothecin showed significant cytotoxic activity.
KW - Icacinaceae
KW - Nothapodytes foetida
KW - camptothecins
KW - cytotoxicity
KW - steroids
UR - http://www.scopus.com/inward/record.url?scp=0029294734&partnerID=8YFLogxK
U2 - 10.1016/0031-9422(94)00901-5
DO - 10.1016/0031-9422(94)00901-5
M3 - 文章
C2 - 7495532
AN - SCOPUS:0029294734
SN - 0031-9422
VL - 39
SP - 383
EP - 385
JO - Phytochemistry
JF - Phytochemistry
IS - 2
ER -