Constituents and cytotoxic principles of Nothapodytes foetida

Tian Shung Wu; Yann Lii Leu; Hua Chun Hsu; Li Fei Ou; Chien Chih Chen; Chieh Fu Chen; Jun Chih Ou; Yang Chang Wu

doi:10.1016/0031-9422(94)00901-5

Constituents and cytotoxic principles of Nothapodytes foetida

Tian Shung Wu^*
, Yann Lii Leu
, Hua Chun Hsu
, Li Fei Ou
, Chien Chih Chen
, Chieh Fu Chen
, Jun Chih Ou
, Yang Chang Wu

^*Corresponding author for this work

National Cheng Kung University
National Research Institute of Chinese Medicine Taiwan
Kaohsiung Medical University

Research output: Contribution to journal › Journal Article › peer-review

61 Scopus citations

Abstract

A new naturally occurring alkaloid, acetylcamptothecin, together with 17 known compounds, (+)-1-hydroxypinoresinol, ω-hydroxypropioguaiacone, p-hydroxybenzaldehyde, scopoletin, uracil, thymine, sitosterol, sitosteryl-β-d-glucoside, 3β-hydroxy-stigmast-5-en-7-one, stigmast-5-en-3β,7α-diol, 6β-hydroxystigmast-4-en-3-one, sitost-4-en-3-one, linoleic acid, trigonelline, camptothecin, 9-O-methoxycamptothecin and pumiloside were isolated and characterized from the stem of Nothapodytes foetida. Among them, scopoletin, camptothecin, 9-O-methoxycamptothecin and O-acetylcamptothecin showed significant cytotoxic activity.

Original language	English
Pages (from-to)	383-385
Number of pages	3
Journal	Phytochemistry
Volume	39
Issue number	2
DOIs	https://doi.org/10.1016/0031-9422(94)00901-5
State	Published - 05 1995
Externally published	Yes

Keywords

Icacinaceae
Nothapodytes foetida
camptothecins
cytotoxicity
steroids

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10.1016/0031-9422(94)00901-5

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title = "Constituents and cytotoxic principles of Nothapodytes foetida",

abstract = "A new naturally occurring alkaloid, acetylcamptothecin, together with 17 known compounds, (+)-1-hydroxypinoresinol, ω-hydroxypropioguaiacone, p-hydroxybenzaldehyde, scopoletin, uracil, thymine, sitosterol, sitosteryl-β-d-glucoside, 3β-hydroxy-stigmast-5-en-7-one, stigmast-5-en-3β,7α-diol, 6β-hydroxystigmast-4-en-3-one, sitost-4-en-3-one, linoleic acid, trigonelline, camptothecin, 9-O-methoxycamptothecin and pumiloside were isolated and characterized from the stem of Nothapodytes foetida. Among them, scopoletin, camptothecin, 9-O-methoxycamptothecin and O-acetylcamptothecin showed significant cytotoxic activity.",

keywords = "Icacinaceae, Nothapodytes foetida, camptothecins, cytotoxicity, steroids",

author = "Wu, \{Tian Shung\} and Leu, \{Yann Lii\} and Hsu, \{Hua Chun\} and Ou, \{Li Fei\} and Chen, \{Chien Chih\} and Chen, \{Chieh Fu\} and Ou, \{Jun Chih\} and Wu, \{Yang Chang\}",

year = "1995",

month = may,

doi = "10.1016/0031-9422(94)00901-5",

language = "英语",

volume = "39",

pages = "383--385",

journal = "Phytochemistry",

issn = "0031-9422",

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T1 - Constituents and cytotoxic principles of Nothapodytes foetida

AU - Wu, Tian Shung

AU - Leu, Yann Lii

AU - Hsu, Hua Chun

AU - Ou, Li Fei

AU - Chen, Chien Chih

AU - Chen, Chieh Fu

AU - Ou, Jun Chih

AU - Wu, Yang Chang

PY - 1995/5

Y1 - 1995/5

N2 - A new naturally occurring alkaloid, acetylcamptothecin, together with 17 known compounds, (+)-1-hydroxypinoresinol, ω-hydroxypropioguaiacone, p-hydroxybenzaldehyde, scopoletin, uracil, thymine, sitosterol, sitosteryl-β-d-glucoside, 3β-hydroxy-stigmast-5-en-7-one, stigmast-5-en-3β,7α-diol, 6β-hydroxystigmast-4-en-3-one, sitost-4-en-3-one, linoleic acid, trigonelline, camptothecin, 9-O-methoxycamptothecin and pumiloside were isolated and characterized from the stem of Nothapodytes foetida. Among them, scopoletin, camptothecin, 9-O-methoxycamptothecin and O-acetylcamptothecin showed significant cytotoxic activity.

AB - A new naturally occurring alkaloid, acetylcamptothecin, together with 17 known compounds, (+)-1-hydroxypinoresinol, ω-hydroxypropioguaiacone, p-hydroxybenzaldehyde, scopoletin, uracil, thymine, sitosterol, sitosteryl-β-d-glucoside, 3β-hydroxy-stigmast-5-en-7-one, stigmast-5-en-3β,7α-diol, 6β-hydroxystigmast-4-en-3-one, sitost-4-en-3-one, linoleic acid, trigonelline, camptothecin, 9-O-methoxycamptothecin and pumiloside were isolated and characterized from the stem of Nothapodytes foetida. Among them, scopoletin, camptothecin, 9-O-methoxycamptothecin and O-acetylcamptothecin showed significant cytotoxic activity.

KW - Icacinaceae

KW - Nothapodytes foetida

KW - camptothecins

KW - cytotoxicity

KW - steroids

UR - https://www.scopus.com/pages/publications/0029294734

U2 - 10.1016/0031-9422(94)00901-5

DO - 10.1016/0031-9422(94)00901-5

M3 - 文章

C2 - 7495532

AN - SCOPUS:0029294734

SN - 0031-9422

VL - 39

SP - 383

EP - 385

JO - Phytochemistry

JF - Phytochemistry

IS - 2

ER -

Constituents and cytotoxic principles of Nothapodytes foetida

Abstract

Keywords

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