Contrast-enhanced optical coherence microangiography with acoustic-Actuated microbubbles

Yu Hsuan Liu; Jia Wei Zhang; Chih Kuang Yeh; Kuo Chen Wei; Hao Li Liu; Meng Tsan Tsai

doi:10.1117/12.2269408

Contrast-enhanced optical coherence microangiography with acoustic-Actuated microbubbles

Yu Hsuan Liu
, Jia Wei Zhang
, Chih Kuang Yeh
, Kuo Chen Wei
, Hao Li Liu
, Meng Tsan Tsai

Department of Electrical Engineering

Chang Gung University
National Tsing Hua University
Chang Gung Memorial Hospital

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

In this study, we propose to use gas-filled microbubbles (MBs) simultaneously actuated by the acoustic wave to enhance the imaging contrast of optical coherence tomography (OCT)-based angiography. In the phantom experiments, MBs can result in stronger backscattered intensity, enabling to enhance the contrast of OCT intensity image. Moreover, simultaneous application of low-intensity acoustic wave enables to temporally induce local vibration of particles and MBs in the vessels, resulting in time-variant OCT intensity which can be used for enhancing the contrast of OCT intensitybased angiography. Additionally, different acoustic modes and different acoustic powers to actuate MBs are performed and compared to investigate the feasibility of contrast enhancement. Finally, animal experiments are performed. The findings suggest that acoustic-Actuated MBs can effectively enhance the imaging contrast of OCT-based angiography and the imaging depth of OCT angiography is also extended.

Original language	English
Title of host publication	Biomedical Imaging and Sensing Conference
Editors	Yasuhiro Awatsuji, Osamu Matoba, Yoshihisa Aizu, Toyohiko Yatagai
Publisher	SPIE
ISBN (Electronic)	9781510610033
DOIs	https://doi.org/10.1117/12.2269408
State	Published - 2017
Event	3rd Biomedical Imaging and Sensing Conference - Yokohama, Japan Duration: 19 04 2017 → 21 04 2017

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	10251
ISSN (Print)	0277-786X
ISSN (Electronic)	1996-756X

Conference

Conference	3rd Biomedical Imaging and Sensing Conference
Country/Territory	Japan
City	Yokohama
Period	19/04/17 → 21/04/17

Bibliographical note

Publisher Copyright:
© 2017 SPIE.

Keywords

Angiography
Microbubbles
Optical Coherence Tomography
Ultrasound

Access to Document

10.1117/12.2269408

Cite this

Liu, Y. H., Zhang, J. W., Yeh, C. K., Wei, K. C., Liu, H. L., & Tsai, M. T. (2017). Contrast-enhanced optical coherence microangiography with acoustic-Actuated microbubbles. In Y. Awatsuji, O. Matoba, Y. Aizu, & T. Yatagai (Eds.), Biomedical Imaging and Sensing Conference Article 102511F (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 10251). SPIE. https://doi.org/10.1117/12.2269408

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title = "Contrast-enhanced optical coherence microangiography with acoustic-Actuated microbubbles",

abstract = "In this study, we propose to use gas-filled microbubbles (MBs) simultaneously actuated by the acoustic wave to enhance the imaging contrast of optical coherence tomography (OCT)-based angiography. In the phantom experiments, MBs can result in stronger backscattered intensity, enabling to enhance the contrast of OCT intensity image. Moreover, simultaneous application of low-intensity acoustic wave enables to temporally induce local vibration of particles and MBs in the vessels, resulting in time-variant OCT intensity which can be used for enhancing the contrast of OCT intensitybased angiography. Additionally, different acoustic modes and different acoustic powers to actuate MBs are performed and compared to investigate the feasibility of contrast enhancement. Finally, animal experiments are performed. The findings suggest that acoustic-Actuated MBs can effectively enhance the imaging contrast of OCT-based angiography and the imaging depth of OCT angiography is also extended.",

keywords = "Angiography, Microbubbles, Optical Coherence Tomography, Ultrasound",

author = "Liu, \{Yu Hsuan\} and Zhang, \{Jia Wei\} and Yeh, \{Chih Kuang\} and Wei, \{Kuo Chen\} and Liu, \{Hao Li\} and Tsai, \{Meng Tsan\}",

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year = "2017",

doi = "10.1117/12.2269408",

language = "英语",

series = "Proceedings of SPIE - The International Society for Optical Engineering",

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}

Liu, YH, Zhang, JW, Yeh, CK, Wei, KC, Liu, HL & Tsai, MT 2017, Contrast-enhanced optical coherence microangiography with acoustic-Actuated microbubbles. in Y Awatsuji, O Matoba, Y Aizu & T Yatagai (eds), Biomedical Imaging and Sensing Conference., 102511F, Proceedings of SPIE - The International Society for Optical Engineering, vol. 10251, SPIE, 3rd Biomedical Imaging and Sensing Conference, Yokohama, Japan, 19/04/17. https://doi.org/10.1117/12.2269408

Contrast-enhanced optical coherence microangiography with acoustic-Actuated microbubbles. / Liu, Yu Hsuan; Zhang, Jia Wei; Yeh, Chih Kuang et al.
Biomedical Imaging and Sensing Conference. ed. / Yasuhiro Awatsuji; Osamu Matoba; Yoshihisa Aizu; Toyohiko Yatagai. SPIE, 2017. 102511F (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 10251).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Contrast-enhanced optical coherence microangiography with acoustic-Actuated microbubbles

AU - Liu, Yu Hsuan

AU - Zhang, Jia Wei

AU - Yeh, Chih Kuang

AU - Wei, Kuo Chen

AU - Liu, Hao Li

AU - Tsai, Meng Tsan

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N2 - In this study, we propose to use gas-filled microbubbles (MBs) simultaneously actuated by the acoustic wave to enhance the imaging contrast of optical coherence tomography (OCT)-based angiography. In the phantom experiments, MBs can result in stronger backscattered intensity, enabling to enhance the contrast of OCT intensity image. Moreover, simultaneous application of low-intensity acoustic wave enables to temporally induce local vibration of particles and MBs in the vessels, resulting in time-variant OCT intensity which can be used for enhancing the contrast of OCT intensitybased angiography. Additionally, different acoustic modes and different acoustic powers to actuate MBs are performed and compared to investigate the feasibility of contrast enhancement. Finally, animal experiments are performed. The findings suggest that acoustic-Actuated MBs can effectively enhance the imaging contrast of OCT-based angiography and the imaging depth of OCT angiography is also extended.

AB - In this study, we propose to use gas-filled microbubbles (MBs) simultaneously actuated by the acoustic wave to enhance the imaging contrast of optical coherence tomography (OCT)-based angiography. In the phantom experiments, MBs can result in stronger backscattered intensity, enabling to enhance the contrast of OCT intensity image. Moreover, simultaneous application of low-intensity acoustic wave enables to temporally induce local vibration of particles and MBs in the vessels, resulting in time-variant OCT intensity which can be used for enhancing the contrast of OCT intensitybased angiography. Additionally, different acoustic modes and different acoustic powers to actuate MBs are performed and compared to investigate the feasibility of contrast enhancement. Finally, animal experiments are performed. The findings suggest that acoustic-Actuated MBs can effectively enhance the imaging contrast of OCT-based angiography and the imaging depth of OCT angiography is also extended.

KW - Angiography

KW - Microbubbles

KW - Optical Coherence Tomography

KW - Ultrasound

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A2 - Awatsuji, Yasuhiro

A2 - Matoba, Osamu

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PB - SPIE

T2 - 3rd Biomedical Imaging and Sensing Conference

Y2 - 19 April 2017 through 21 April 2017

ER -

Contrast-enhanced optical coherence microangiography with acoustic-Actuated microbubbles

Abstract

Publication series

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Bibliographical note

Keywords

Access to Document

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