Control of cisplatin-induced emesis with intravenous ondansetron plus intravenous dexamethasone: A crossover study of triple 8-mg dose of ondansetron

Chuang Chi Liaw*, Cheng Hsu Wang, Hsien Kun Chang, Chen Yi Kao, Jen Sheng Huang

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

10 Scopus citations

Abstract

Two hundred seventy-five patients were enrolled in one of two arms in a crossover fashion. Arm A: Three 8-mg doses of ondansetron intravenous (IV) were given at 4-hour intervals plus dexamethasone 20 mg IV from the start of chemotherapy followed by dexamethasone 5 mg IV every 12 hours. Arm B: As in arm A but with three 8-mg doses of ondansetron IV were given at 24-hour intervals substituted for ondansetron IV given at 4-hour intervals. There were 237 patients in arm A and 223 patients in arm B. Complete protection from acute and delayed vomiting/nausea obtained in arm A was 94.5%/90.3% and 71.3%/57.8%, respectively; protection obtained in arm B was 92.7%/91.0% and 71.7%/60.5%, respectively. No differences were observed in control of acute emesis after the addition of dexamethasone to ondansetron, given as either a triple 8-mg dose at 4-hour intervals or a single 8-mg dose. The triple dose of ondansetron given at 24-hour intervals was also not more effective than ondansetron given at 4-hour intervals in preventing delayed emesis when dexamethasone was added. However, the former improved control of delayed nausea on day 2. Adverse events tended to be minor, with constipation and hiccup the most common.

Original languageEnglish
Pages (from-to)253-257
Number of pages5
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume23
Issue number3
DOIs
StatePublished - 2000

Keywords

  • Cisplatin
  • Dexamethasone
  • Emesis
  • Ondansetron

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