Correlated effects of clonidine on single-neuron activities in the gigantocellular reticular nucleus, arterial pressure and heart rate in the cat

Samuel H.H. Chan; Julie Y.H. Chan

doi:10.1016/0304-3940(83)90292-6

Correlated effects of clonidine on single-neuron activities in the gigantocellular reticular nucleus, arterial pressure and heart rate in the cat

Samuel H.H. Chan^*, Julie Y.H. Chan

^*Corresponding author for this work

National University of Singapore

Research output: Contribution to journal › Journal Article › peer-review

19 Scopus citations

Abstract

In chloralose-urethane anesthetized cats, intravenous administration of clonidine (10 μg/kg) promoted an increase in single-neuron discharges in the gigantocellular reticular nucleus that exhibited a degree and time-course parallel to the hypotension and bradycardia produced by the imidazoline compound. This observation was taken to be a positive indication that clonidine may pharmacoligically activate (or disinhibit) neurons in this reticular nucleus, which in turn elicits vasodepression and cardioinhibition.

Original language	English
Pages (from-to)	139-143
Number of pages	5
Journal	Neuroscience Letters
Volume	40
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(83)90292-6
State	Published - 30 09 1983
Externally published	Yes

Keywords

bradycardia
cat
clonidine
gigantocellular reticular nucleus
hypotension
single-neuron discharges

Access to Document

10.1016/0304-3940(83)90292-6

Cite this

@article{ac432caf771c42d1a30ed487ed3f1d87,

title = "Correlated effects of clonidine on single-neuron activities in the gigantocellular reticular nucleus, arterial pressure and heart rate in the cat",

abstract = "In chloralose-urethane anesthetized cats, intravenous administration of clonidine (10 μg/kg) promoted an increase in single-neuron discharges in the gigantocellular reticular nucleus that exhibited a degree and time-course parallel to the hypotension and bradycardia produced by the imidazoline compound. This observation was taken to be a positive indication that clonidine may pharmacoligically activate (or disinhibit) neurons in this reticular nucleus, which in turn elicits vasodepression and cardioinhibition.",

keywords = "bradycardia, cat, clonidine, gigantocellular reticular nucleus, hypotension, single-neuron discharges",

author = "Chan, {Samuel H.H.} and Chan, {Julie Y.H.}",

year = "1983",

month = sep,

day = "30",

doi = "10.1016/0304-3940(83)90292-6",

language = "英语",

volume = "40",

pages = "139--143",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Correlated effects of clonidine on single-neuron activities in the gigantocellular reticular nucleus, arterial pressure and heart rate in the cat

AU - Chan, Samuel H.H.

AU - Chan, Julie Y.H.

PY - 1983/9/30

Y1 - 1983/9/30

N2 - In chloralose-urethane anesthetized cats, intravenous administration of clonidine (10 μg/kg) promoted an increase in single-neuron discharges in the gigantocellular reticular nucleus that exhibited a degree and time-course parallel to the hypotension and bradycardia produced by the imidazoline compound. This observation was taken to be a positive indication that clonidine may pharmacoligically activate (or disinhibit) neurons in this reticular nucleus, which in turn elicits vasodepression and cardioinhibition.

AB - In chloralose-urethane anesthetized cats, intravenous administration of clonidine (10 μg/kg) promoted an increase in single-neuron discharges in the gigantocellular reticular nucleus that exhibited a degree and time-course parallel to the hypotension and bradycardia produced by the imidazoline compound. This observation was taken to be a positive indication that clonidine may pharmacoligically activate (or disinhibit) neurons in this reticular nucleus, which in turn elicits vasodepression and cardioinhibition.

KW - bradycardia

KW - cat

KW - clonidine

KW - gigantocellular reticular nucleus

KW - hypotension

KW - single-neuron discharges

UR - http://www.scopus.com/inward/record.url?scp=0020610287&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(83)90292-6

DO - 10.1016/0304-3940(83)90292-6

M3 - 文章

C2 - 6314205

AN - SCOPUS:0020610287

SN - 0304-3940

VL - 40

SP - 139

EP - 143

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Correlated effects of clonidine on single-neuron activities in the gigantocellular reticular nucleus, arterial pressure and heart rate in the cat

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this