Correlation of age with the status of hepatitis B virus replication and histological changes in chronic type B hepatitis

Chia‐Hua‐Ming ‐H ‐M Chu, Yun‐Fan ‐F Liaw*, I‐Shyan ‐S Sheen, Tong‐Jong ‐J Chen

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

22 Scopus citations


ABSTRACT— The interrelationships of age, hepatitis B virus (HBV)‐DNA, hepatitis B e antigen (HBeAg)/antibody (anti‐HBe) and hepatic histological changes were examined in a large series of patients with chronic type B hepatitis. A significant inverse relationship between serum levels of HBV‐DNA and the age of patients was demonstrated:a high level of HBV‐DNA (> 500 pg/ml) was found in 100%, 50%, 34%, 10% and 0% of patients in the second, third, fourth, fifth and sixth decade, respectively (P<0.001), whereas serum HBV‐DNA was negative in 0%, 6%, 8%, 40%, and 50% of cases in the respective decades (P<0.001). The correlation of HBV‐DNA with age was more pronounced in the HBeAg‐negative cases, of whom 81.3% (13/16) of patients below age 40 were positive for HBV‐DNA, in contrast to 33.3% (3/9) of those over 40 years (P<0.05). In addition, the mean age increased from 25.3 years for HBeAg‐positive patients with chronic persistent hepatitis (CPH) and nonspecific reactive histological changes (NSRH), to 32.7 years for HBeAg‐positive and 34.9 years for anti‐HBe positive patients with chronic active hepatitis and chronic lobular hepatitis (P<0.001), and 40.9 years for anti‐HBe positive CPH and NSRH (P<0.001). These data suggested that age correlated closely with the status of HBV replication and hepatic changes in chronic type B hepatitis.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
Issue number3
StatePublished - 06 1985
Externally publishedYes


  • age
  • chronic type B hepatitis
  • hepatitis B e antigen
  • hepatitis B virus‐DNA


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