Correlation of fecundability and serum estradiol after danazol treatment in patients with advanced endometriosis

F. P. Chen*, K. K. Chu, Y. K. Soong

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

1 Scopus citations

Abstract

Objective: To examine the relationship between pregnancy incidence and the level of serum E2 during danazol therapy. Design: Danazol was given by 200 mg four times daily for 3 months. Serum E2 level was checked after completing the therapy, but before stopping medication. Patients then were advised to conceive at the appropriate time over a 6-month period. Setting: Reproductive and Endocrine Laboratory of the Department of Obstetrics and Gynecology, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan. Patients: Infertile women with invasive endometriosis receiving conservative surgery and danazol treatment. Interventions: Serum E2 is checked before medication and at the end of danazol therapy, but before stopping medication. Main Outcome Measures: Whether pregnancy is related to the change of serum E2 caused by danazol therapy. Results: There were 24 pregnancies in 38 patients with invasive endometriosis after treatment. Pregnant patients had significantly lower serum E2 levels as compared with the nonpregnant patients. Conclusions: After conservative surgery for invasive endometriosis associated with infertility, the therapeutic period of danazol treatment could be shortened to 3 months. Because there is significant correlation of fecundability and serum E2 after danazol medication, serum E2 could be a guideline for predicting pregnancy or for prolonging or changing of treatment after danazol therapy.

Original languageEnglish
Pages (from-to)1232-1234
Number of pages3
JournalFertility and Sterility
Volume65
Issue number6
DOIs
StatePublished - 1996

Keywords

  • Danazol
  • fecundability
  • invasive endometriosis
  • serum E

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