Abstract
Purpose: The aims of this study were to investigate the hypometabolic regions of FDG PET compared with the nigrostriatal dopamine pathway abnormalities in TRODAT-1 scan in patients with dementia with Lewy bodies (DLBs) at mild and dementia stages as well as to validate the correlation among networks being constructed with clinical data.
Materials and Methods: A total of 25 DLB patients were classified into 2 functional groups stratified by the Clinical Dementia Rating (CDR) Scale (CDR 0.5: n = 14, mild stage; CDR 1 or 2: n = 11, dementia stage) compared with 9 agematched controls. Neuroimaging survey was applied using information derived from FDG PET by performing voxel-based analysis and a semiquantitative 99mTc-TRODAT-1 scan to correlate these results with the cognitive and Unified Parkinson's Disease Rating Scale.
Results: Compared with normal database, the patients with mild stage showed hypometabolismin the temporal regions, anterior cingulate cortex, inferior orbital region, thalamus, and caudate nucleus. Although at the dementia stage, more extensive cortical hypometabolism involving occipital region were found. The dopamine transporter levels derived from TRODAT-1 scan had excellent discrimination in diagnosing DLB compared with age-matched normal controls (1.58 [0.2] and 1.84 [0.1], P < 0.01) but without significant differences between mild and dementia stages. The sophisticated cortical-brainstemnetworks by FDG PET and TRODAT-1 yielded good clinical correlation.
Conclusions: The networks yielded from FDG PET and TRODAT-1 revealed good correlation with clinical data and that nigrostriatal pathway abnormalities are preceded by typical occipital hypometabolism in mild stage of DLB. Dopamine transporter levels may serve as early diagnostic tool and FDG PET as staging indicator for DLB pathology.
Original language | English |
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Pages (from-to) | 26-31 |
Number of pages | 6 |
Journal | Clinical Nuclear Medicine |
Volume | 40 |
Issue number | 1 |
DOIs | |
State | Published - 14 01 2015 |
Keywords
- Clinical Dementia Rating
- Dementia with Lewy bodies
- FDG
- PET
- TRODAT-1